Anti-TMPRSS13抗体-细胞质domain (ab59862)
Key features and details
- Rabbit polyclonal to TMPRSS13
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-TMPRSS13抗体-细胞质domain -
描述
兔多克隆抗体to TMPRSS13 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide based on the cytoplasmic domain of human TMPRSS13. Immunizing peptide available on request - please contact a member of staff to ask for availability
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: PBS, 50% Glycerol, 2.9% Sodium chloride -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab59862于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use at an assay dependent dilution. Predicted molecular weight: 63 kDa. A recommended starting concentration for Western blots is 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates.
|
| 说明 |
|---|
|
WB
Use at an assay dependent dilution. Predicted molecular weight: 63 kDa. A recommended starting concentration for Western blots is 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates. |
靶标
-
组织特异性
Isoform 1 and isoform 3 are predominantly expressed in lung, placenta, pancreas, and prostate. Isoform 3 is weakly expressed in testis and peripheral blood lymphocytes. -
序列相似性
Belongs to the peptidase S1 family.
Contains 1 LDL-receptor class A domain.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain. -
细胞定位
Membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 84000 Human
- Omim: 610050 Human
- SwissProt: Q9BYE2 Human
- Unigene: 266308 Human
-
别名
- Membrane-type mosaic serine protease antibody
- Mosaic serine protease antibody
- MSP antibody
see all
图片
-
Western blot - Anti-TMPRSS13 antibody - Cytoplasmic domain (ab59862)All lanes : Anti-TMPRSS13 antibody - Cytoplasmic domain (ab59862) at 1/1000 dilution
Lane 1 : Cell media from human prostate adenocarcinoma LNCaP cells (treated with SF)
Lane 2 : Cell media from human prostate adenocarcinoma LNCaP cells (treated with TPA)
Lane 3 : Cell media from human prostate adenocarcinoma LNCaP cells (treated with IL1-alpha)
Lysates/proteins at 20 µl per lane.
Predicted band size: 63 kDa
数据表及文件
-
SDS download
-
Datasheet download
文献 (5)
ab59862 被引用在 5 文献中.
- Gatineau J et al. IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike. Front Immunol 13:982839 (2022). PubMed: 36131918
- Stevaert A et al. Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 Protease. mBio 13:e0137622 (2022). PubMed: 35913162
- Martin CE et al. Posttranslational modifications of serine protease TMPRSS13 regulate zymogen activation, proteolytic activity, and cell surface localization. J Biol Chem 297:101227 (2021). PubMed: 34562451
- Varela FA et al. TMPRSS13 promotes cell survival, invasion, and resistance to drug-induced apoptosis in colorectal cancer. Sci Rep 10:13896 (2020). PubMed: 32807808
- Murray AS et al. Phosphorylation of the type II transmembrane serine protease, TMPRSS13, in hepatocyte growth factor activator inhibitor-1 and -2-mediated cell-surface localization. J Biol Chem 292:14867-14884 (2017). PubMed: 28710277