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AB121349

Anti-TMEM109/Mitsugumin-23抗体

Anti-TMEM109/Mitsugumin-23 antibody

4

(4 Reviews)

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(1 Publication)

Rabbit Polyclonal TMEM109/Mitsugumin-23 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM109 aa 200 to C-terminus.

查看别名

Voltage-gated monoatomic cation channel TMEM109, Mitsugumin-23, Transmembrane protein 109, Mg23, TMEM109

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM109/Mitsugumin-23 antibody (AB121349)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM109/Mitsugumin-23 antibody (AB121349)

ab121349, at 1/1000, staining TMEM109/Mitsugumin-23 in Paraffin-embedded Human pancreas tissue by Immunohistochemistry.
Note : strong cytoplasmic positivity in exocrine glandular cells.

Immunocytochemistry/ Immunofluorescence - Anti-TMEM109/Mitsugumin-23 antibody (AB121349)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TMEM109/Mitsugumin-23 antibody (AB121349)

ab121349 at 4 μg/ml staining TMEM109/Mitsugumin-23 in PFA/Triton X-100 fixed/permeabilized U 251 MG cells by Immunofluorescence (green).
Note : positivity in nucleus but not nucleoli, nuclear membrane and cytoplasm.

Western blot - Anti-TMEM109/Mitsugumin-23 antibody (AB121349)
  • WB

Unknown

Western blot - Anti-TMEM109/Mitsugumin-23 antibody (AB121349)

All lanes:

Western blot - Anti-TMEM109/Mitsugumin-23 antibody (ab121349) at 1/250 dilution

Lane 1:

RT4 lysate

Lane 2:

U 251 MG lysate

Lane 3:

Human plasma lysate

Lane 4:

Human liver lysate

Lane 5:

Human tonsil lysate

Predicted band size: 26 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

ICC/IF, WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human TMEM109 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BVC6

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TMEM109 also known as Mitsugumin-23 (MG23) functions as a transmembrane protein with a mass of approximately 20-25 kDa. It resides in the endoplasmic reticulum membrane where it acts as an important component in maintaining cellular homeostasis. This protein is primarily observed across various tissues with a higher expression in muscle tissue and certain types of epithelial cells. Its structure suggests roles in calcium signaling due to domains that allow ion passage across cellular membranes.
Biological function summary

TMEM109 plays a role in the regulation of calcium ion concentrations within cells contributing to the mitochondrial permeability transition pore (MPTP) complex. This complex controls mitochondrial function by regulating the passage of ions and small metabolites which is critical for cell survival and apoptosis. Through these activities TMEM109 influences processes like muscle contraction and cell death highlighting its significance in cellular energy management and programmed cell death pathways.

Pathways

TMEM109 has roles in calcium signaling and apoptotic pathways two significant biological processes for cellular health. In the calcium signaling pathway it interacts with other proteins such as SERCA1 (Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 1) to help manage calcium ion levels within cells. In apoptotic pathways TMEM109's involvement in the MPTP complex links it to the BAX protein which is an essential regulator of apoptosis facilitating the release of cytochrome c from mitochondria triggering cascade events leading to cell death.

Irregular function or expression of TMEM109 associates with conditions such as muscular dystrophy and neurodegenerative disorders. For example in muscular dystrophy altered calcium regulation and signaling through MG23 may impact muscle contraction and integrity. Additionally abnormal TMEM109 activity can connect to Alzheimer’s disease where disrupted calcium homeostasis and apoptotic signaling play roles. These disease connections make TMEM109 a considerable target for therapeutic research and intervention often intersecting pathways with proteins like dystrophin in muscular dystrophy cases and amyloid precursor protein (APP) in Alzheimer's disease.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Functions as a voltage-gated monoatomic cation channel permeable to both potassium and calcium (By similarity). Plays a role in the cellular response to DNA damage (PubMed : 23542032).
See full target information TMEM109
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cell metabolism 35:2183-2199.e7 PubMed38006878

2023

PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2.

Applications

Unspecified application

Species

Unspecified reactive species

Cong Jiang,Jing Liu,Shaohui He,Wei Xu,Runzhi Huang,Weijuan Pan,Xiaolong Li,Xiaoming Dai,Jianping Guo,Tao Zhang,Hiroyuki Inuzuka,Ping Wang,John M Asara,Jianru Xiao,Wenyi Wei
View all publications
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