Anti-TLR8抗体(ab53630)
Key features and details
- Goat polyclonal to TLR8
- Suitable for: IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-TLR8抗体
参阅全部 TLR8 一抗 -
描述
山羊多克隆抗体to TLR8 -
宿主
Goat -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Synthetic peptide:
CESFQGLQNLTKINLNHNPNVQHQNGNPGI
, corresponding to amino acids 81-109 of Human TLR8 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.1% Sodium azide
Constituents: 0.1% BSA, 0.21% Potassium phosphate, 0.812% Sodium chloride, PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab53630于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
IHC-P
Use at an assay dependent concentration. |
靶标
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功能
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. -
组织特异性
Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells. -
序列相似性
Belongs to the Toll-like receptor family.
Contains 23 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 TIR domain. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 51311 Human
- Entrez Gene: 170744 Mouse
- Omim: 300366 Human
- SwissProt: Q9NR97 Human
- SwissProt: P58682 Mouse
- Unigene: 660543 Human
- Unigene: 196676 Mouse
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别名
- CD 288 antibody
- CD288 antibody
- CD288 antigen antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLR8 antibody (ab53630)ab53630 at 1/250 dilution staining TLR8 in mouse spleen by Immunohistochemistry, Paraffin embedded tissue.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLR8 antibody (ab53630)ab53630 at 1/250 dilution staining TLR8 in human tonsil by Immunohistochemistry, Paraffin embedded tissue.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab53630 被引用在 3 文献中.
- Wang Y et al. Increased infiltration of CD11 c+/CD123+ dendritic cell subsets and upregulation of TLR/IFN-a signaling participate in pathogenesis of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol 125:459-467.e2 (2018). IHC-P . PubMed: 29429903
- Jiang C et al. The Expression of Toll-like receptors in eutopic and ectopic endometrium and its implication in the inflammatory pathogenesis of adenomyosis. Sci Rep 7:7365 (2017). PubMed: 28779087
- Thiyagarajan D et al. Silencing of Renal DNaseI in Murine Lupus Nephritis Imposes Exposure of Large Chromatin Fragments and Activation of Toll Like Receptors and the Clec4e. PLoS One 7:e34080 (2012). PubMed: 22479529