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AB24184

Anti-TLR7抗体

Anti-TLR7 antibody

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(5 Publications)

Rabbit Polyclonal TLR7 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Mouse Tlr7.

查看别名

UNQ248/PRO285, TLR7, Toll-like receptor 7

2 Images
Western blot - Anti-TLR7 antibody (AB24184)
  • WB

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Western blot - Anti-TLR7 antibody (AB24184)

Lane 1:

Western blot - Anti-TLR7 antibody (ab24184) at 0.5 µg/mL

Lane 2:

Western blot - Anti-TLR7 antibody (ab24184) at 1 µg/mL

Lane 3:

Western blot - Anti-TLR7 antibody (ab24184) at 2 µg/mL

All lanes:

Daudi cell lysates

Predicted band size: 121 kDa

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Immunocytochemistry/ Immunofluorescence - Anti-TLR7 antibody (AB24184)
  • ICC/IF

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Immunocytochemistry/ Immunofluorescence - Anti-TLR7 antibody (AB24184)

ab24184 at 2μg/ml staining of TLR7 in Daudi cells by ICC/IF

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

Synthetic Peptide within Mouse Tlr7. The exact immunogen used to generate this antibody is proprietary information.

P58681

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化说明
Ion exchange chromatography purified IgG.
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TLR7 also known as Toll-like receptor 7 plays a mechanical role in the immune system by recognizing single-stranded RNA molecules. This receptor with a mass of approximately 120 kDa is a member of the Toll-like receptor family. TLR7 mainly expresses in immune cells like plasmacytoid dendritic cells and B cells. Its location on the endosomal surface allows it to detect viral RNA and trigger downstream signaling cascades.
Biological function summary

TLR7 induces an immune response by activating pathways that lead to the production of cytokines and type I interferons. It does not function alone but interacts within a complex involving other adaptors such as MyD88. This interaction initiates a signaling cascade that is essential for mounting an acute response to viral infections and boosting adaptive immunity.

Pathways

Single-stranded RNA detection through TLR7 activates the MyD88-dependent pathway which is important for innate immune responses. This pathway includes key components such as NF-κB and IRF7 leading to inflammatory cytokine production. TLR7 links with these proteins working together to activate the host defense mechanism against viral infections.

TLR7 plays a significant role in autoimmunity and viral infections. Aberrant activation of TLR7 has connections with systemic lupus erythematosus (SLE) where it may contribute to pathogenesis by promoting autoantibody production. Additionally TLR7 influences the immune response in chronic infections like hepatitis C where it operates with proteins like MyD88 and contributes to disease progression and severity.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed : 14976261, PubMed : 32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed : 12738885, PubMed : 27742543, PubMed : 31608988, PubMed : 32706371, PubMed : 35477763). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed : 27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed : 27742543, PubMed : 32706371).
See full target information TLR7
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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular physiology 238:257-273 PubMed36436135

2022

Keratinocyte TLR2 and TLR7 contribute to chronic itch through pruritic cytokines and chemokines in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Zhi-Hong Wang,Yu Feng,Qingfang Hu,Xue-Long Wang,Li Zhang,Teng-Teng Liu,Jiang-Tao Zhang,Xiaohua Yang,Qing-Yue Fu,Dan-Ni Fu,Ji Hu,Tong Liu

Frontiers in immunology 12:637659 PubMed33767707

2021

Activation of Toll-Like Receptor 7 Signaling Pathway in Primary Sjögren's Syndrome-Associated Thrombocytopenia.

Applications

Unspecified application

Species

Unspecified reactive species

Shuo Zhang,Jingge Qu,Li Wang,Mengtao Li,Dong Xu,Yan Zhao,Fengchun Zhang,Xiaofeng Zeng

Frontiers in immunology 11:607442 PubMed33488612

2021

Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis.

Applications

Unspecified application

Species

Unspecified reactive species

Binhui Zhou,Wenyi Yang,Wushan Li,Le He,Liaoxun Lu,Lichen Zhang,Zhuangzhuang Liu,Ying Wang,Tianzhu Chao,Rong Huang,Yanrong Gu,Tingting Jia,Qiaoli Liu,Shuanghua Tian,Philippe Pierre,Takahiro Maeda,Yinming Liang,Eryan Kong

Archives of physiology and biochemistry :1-5 PubMed31311339

2019

The miR-122 inhibition alleviates lipid accumulation and inflammation in NAFLD cell model.

Applications

Unspecified application

Species

Unspecified reactive species

Yiyi Hu,Guoping Du,Guohua Li,Xuetao Peng,Zhiqiao Zhang,Yingji Zhai

The EMBO journal 27:1110-21 PubMed18337753

2008

Toll-like receptors control autophagy.

Applications

WB

Species

Mouse

Mónica A Delgado,Rasha A Elmaoued,Alexander S Davis,George Kyei,Vojo Deretic
View all publications
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