AB168382

重组Anti-TLR5抗体[EPR10373]

Anti-TLR5 antibody [EPR10373]

RabMAb
Recombinant
了解详情

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(5 Publications)

Rabbit Recombinant Monoclonal TLR5 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications.

查看别名

TIL3, TLR5, Toll-like receptor 5, Toll/interleukin-1 receptor-like protein 3

1 Images

Unknown

Western blot - Anti-TLR5 antibody [EPR10373] (AB168382)

All lanes:

Western blot - Anti-TLR5 antibody [EPR10373] (ab168382) at 1/1000 dilution

Lane 1:

HT29 cell lysate at 10 µg

Lane 2:

A549 cell lysate at 10 µg

Lane 3:

THP1 cell lysate at 10 µg

Lane 4:

HeLa cell lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 97 kDa

false

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR10373

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯度

Tissue culture supernatant

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Toll-like receptor 5 (TLR5) also known as CD285 is a protein that functions mechanically as a pattern recognition receptor. It has a mass of about 98 kDa and is expressed mainly in the tissues of the lung intestine and urogenital tract. TLR5 recognizes pathogen-associated molecular patterns specifically identifying and binding to flagellin a protein component of bacterial flagella. This engagement initiates a signaling cascade that results in an immune response.

Biological function summary

This receptor plays a central role in the innate immune system. TLR5 is part of a complex network of receptors that detect microbial infections and activate immune defense. When TLR5 binds to flagellin it triggers the production of inflammatory cytokines and activation of adaptive immune responses. This interaction helps in mobilizing immune cells to the site of infection providing the body with a robust defense mechanism against bacterial pathogens.

Pathways

TLR5 activation is an important component of the NF-kB signaling and MAPK pathways. These pathways lead to the transcription of genes involved in inflammation and immune response. TLR5 interacts with MyD88 an adaptor protein to facilitate the downstream signaling cascade. This involvement links TLR5 to not only NF-kB pathway but also connects it to other Toll-like receptors further integrating the immune signaling network.

TLR5 has been connected to inflammatory bowel disease and chronic obstructive pulmonary disease (COPD). Abnormal TLR5 signaling can lead to excessive inflammation contributing to these conditions. In COPD TLR5 and its associated cytokines can exacerbate lung inflammation while in inflammatory bowel disease dysregulation may trigger improper intestinal immune responses. Research into TLR5's role in these diseases can illuminate potential therapeutic targets.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed : 11323673, PubMed : 18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed : 29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed : 11489966, PubMed : 20855887). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).

See full target information TLR5

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 22:1227 PubMed34539823

2021

Upregulating miR-27a-3p inhibits cell proliferation and inflammation of rheumatoid arthritis synovial fibroblasts through targeting toll-like receptor 5.

Applications

Unspecified application

Species

Unspecified reactive species

Lifeng Chen,Qiping Lu,Jianhua Chen,Ruibing Feng,Chenxi Yang

Cell death & disease 10:954 PubMed31852883

2019

TLR5: A prognostic and monitoring indicator for triple-negative breast cancer.

Applications

Unspecified application

Species

Mouse

Dai Shi,Shanshan Zhao,Wen Jiang,Chao Zhang,Ting Liang,Guihua Hou

Inflammatory bowel diseases 23:392-403 PubMed28146004

2017

Epithelial-specific Toll-like Receptor (TLR)5 Activation Mediates Barrier Dysfunction in Experimental Ileitis.

Applications

Unspecified application

Species

Unspecified reactive species

Loris R Lopetuso,Ruo Jia,Xiao-Ming Wang,Li-Guo Jia,Valentina Petito,Wendy A Goodman,Jon B Meddings,Fabio Cominelli,Brian K Reuter,Theresa T Pizarro

Scandinavian journal of immunology 85:220-226 PubMed27943374

2016

Expression of Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Patients with Primary Sjögren's Syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

M Karlsen,K Jakobsen,R Jonsson,D Hammenfors,T Hansen,S Appel

Mucosal immunology 8:1000-8 PubMed25563498

2015

Suppression of Toll-like receptor-mediated innate immune responses at the ocular surface by the membrane-associated mucins MUC1 and MUC16.

Applications

Unspecified application

Species

Unspecified reactive species

B B Menon,C Kaiser-Marko,S Spurr-Michaud,A S Tisdale,I K Gipson

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组Anti-TLR5抗体[EPR10373]

Anti-TLR5 antibody [EPR10373]

Western blot - Anti-TLR5 antibody [EPR10373] (AB168382)

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

免疫原