Anti-TLR2抗体[TL2.1]
Anti-TLR2 antibody [TL2.1]
4
(9 Reviews)
|
(40 Publications)
Mouse Monoclonal TLR2 antibody. Suitable for IP, Flow Cyt, WB, FuncS, FuncS (Neut/Block), ICC/IF and reacts with Common marmoset, Cynomolgus monkey, Rhesus monkey, Human, Dog samples. Cited in 40 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TLR2.
查看别名
CD282, TIL4, TLR2, Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4
- Flow Cyt
Unknown
Flow Cytometry - Anti-TLR2 antibody [TL2.1] (AB9100)
TLR2 staining on human peripheral blood mononuclear cells by using ab9100. Green : CD3+-cells; Red : CD14+ cells
- WB
Lab
Western blot - Anti-TLR2 antibody [TL2.1] (AB9100)
This blot was produced using a 4-12% Bis-Tris gel under the MOPS buffer system. The gel was ran at 200V for 60 minutes before being transferred onto a nitrocellulose membrane at 30V for 70 minutes. The membrane was then blocked with 2% BSA for 60 minutes before being incubated with ab9100 (anti-TLR2 antibody; 1 ug/mL) for 18 hours at 4°C. Antibody binding was detected using ab97040 (HRP-labelled goat anti-mouse IgG) at 1 : 50,000 dilutions for 1 hour at room temperature.Visualisation was conducted using ECL development solution ab133406.
This gel was run under reducing conditions resulting in weak signal. We recommend customers to use non-reducing conditions.
All lanes:
Western blot - Anti-TLR2 antibody [TL2.1] (ab9100) at 1 µg/mL
Lane 1:
THP1 at 20 µg
Lane 2:
THP1 + LPS at 20 µg
Secondary
All lanes:
Western blot - Goat Anti-Mouse IgG H&L (HRP) preadsorbed (<a href='/products/secondary-antibodies/goat-mouse-igg-h-l-hrp-preadsorbed-ab97040'>ab97040</a>) at 1/50000 dilution
Predicted band size: 89 kDa
false
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性能和储存信息
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存储溶液
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推荐的短期储存条件
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补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
TLR2 initiates signaling pathways that lead to the production of cytokines and chemokines helping to control infection. It forms dimers with other TLRs like TLR1 or TLR6 to expand its recognition range of microbial components. TLR2's activity is important for balancing pathogen recognition and avoiding overactive immune response. On macrophages TLR2 activation enhances their phagocytic ability.
Pathways
TLR2 plays roles in innate immune signaling pathways and inflammation pathways. It contributes significantly to the NF-kB and MAPK pathways which regulate inflammation and immune response. TLR2 often cooperates with proteins like MyD88 and TRAF6 in these pathways leading to downstream activation of transcription factors and production of pro-inflammatory molecules.
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靶点信息
文献 (40)
Recent publications for all applications. Explore the full list and refine your search
Respiratory research 26:131 PubMed40205554
2025
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Materials today. Bio 31:101484 PubMed39925716
2025
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Oncology letters 27:16 PubMed38028174
2023
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International journal of molecular sciences 23: PubMed36293206
2022
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International immunopharmacology 100:108155 PubMed34543981
2021
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Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8:e2004852 PubMed34180133
2021
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Cell death & disease 12:477 PubMed33980825
2021
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American journal of reproductive immunology (New York, N.Y. : 1989) 85:e13370 PubMed33152143
2020
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Journal of neuroimmune pharmacology : the official 14:688-696 PubMed31321663
2019
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PloS one 14:e0215234 PubMed30978209
2019
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