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AB17218

Anti-TIRAP抗体

Anti-TIRAP antibody

5

(2 Reviews)

|

(16 Publications)

Rabbit Polyclonal TIRAP antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 16 publications. Immunogen corresponding to Synthetic Peptide within Human TIRAP.

查看别名

Adapter protein wyatt, FLJ42305, MyD88 adapter like protein, TIR domain containing adapter protein, Toll interleukin 1 receptor (TIR) domain containing adaptor protein, Toll interleukin 1 receptor domain containing adapter protein, Toll like receptor adaptor protein, Wyatt

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIRAP antibody (AB17218)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIRAP antibody (AB17218)

ab17218 at 2μg/ml staining TIRAP in human heart cells by IHC

Western blot - Anti-TIRAP antibody (AB17218)
  • WB

Unknown

Western blot - Anti-TIRAP antibody (AB17218)

Western Blot of human heart lysate labeling TIRAP with Anti-TIRAP antibody (ab17218) at (1) 1 and (2) 2μg/ml.

All lanes:

Western blot - Anti-TIRAP antibody (ab17218)

Predicted band size: 24 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human, Rat, Mouse

应用

IHC-P, WB, ICC/IF

applications

免疫原

Synthetic Peptide within Human TIRAP. The exact immunogen used to generate this antibody is proprietary information.

P58753

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替代产品

Primary Antibodies

AB13684

Anti-TIRAP antibody [20D1055]

Western blot - Anti-TIRAP antibody [20D1055] (AB13684)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB32536

Anti-NF-kB p65 antibody [E379]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NF-kB p65 antibody [E379] (AB32536)

  • 4
  • 15
Primary Antibodies

AB92700

Anti-IKB alpha (phospho S32) antibody [EPR3148]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-IKB alpha (phospho S32) antibody [EPR3148] (AB92700)

  • 5
  • 1
Primary Antibodies

AB76302

Anti-NF-kB p65 (phospho S536) antibody [EP2294Y]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-NF-kB p65 (phospho S536) antibody [EP2294Y] (AB76302)

  • 4
  • 7
Primary Antibodies

AB52915

Anti-MMP3 antibody [EP1186Y]

20ul selling size|KO Validated|RabMAb|Recombinant

Western blot - Anti-MMP3 antibody [EP1186Y] (AB52915)

  • 5
  • 4
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "2 µg/mL", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "2 µg/mL", "IHCP-species-notes": "<p></p>" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
纯化说明
ab17218 is purified by ion exchange chromatography.TIRAP Antibody is affinity chromatography purified via peptide column.
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
储存信息
Avoid freeze / thaw cycle|Stable for 12 months at -20°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TIRAP also known as Mal is an adapter protein integral to the Toll-like receptor (TLR) signaling pathway. It has a molecular mass of approximately 24 kDa. TIRAP resides mostly in the cytoplasm and gets recruited to the plasma membrane where it assists in signal transduction. It plays a significant role in bridging TLRs such as TLR2 and TLR4 with downstream signaling elements like MyD88. This protein mediates the recruitment of other signaling proteins after TLR activation therefore facilitating the innate immune response.
Biological function summary

TIRAP is part of the innate immune system and contributes to the immune response against pathogens. It forms part of a signaling complex that leads to the activation of NF-kB and MAP kinase pathways resulting in the production of inflammatory cytokines. The protein works by directly interacting with phosphatidylinositol 45-bisphosphate at the plasma membrane through its phosphoinositide-binding motif. This interaction ensures that TIRAP is correctly positioned to relay signals for immune activation.

Pathways

TIRAP functions in the MyD88-dependent signaling pathway which is significant for initiating inflammatory responses. TIRAP and MyD88 work in tandem to propagate signals from activated TLRs. This relationship not only aids in inflammation but also in the differentiation of immune cells. TIRAP is also related to other proteins like IRAK1 in these pathways which further transduces signals leading to downstream activation of transcription factors relevant for immune responses.

TIRAP plays a part in conditions like systemic lupus erythematosus and septic shock. Mutations in the TIRAP gene can alter the signaling cascade leading to aberrant immune responses associated with these diseases. In this context TIRAP interacts with TLR4 and any dysfunction in the interaction may contribute to the excessive inflammation seen in septic shock. Understanding TIRAP's role in these diseases provides insight into targeted therapeutic strategies.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

See full target information TIRAP
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文献 (16)

Recent publications for all applications. Explore the full list and refine your search

Experimental & molecular medicine 56:2588-2601 PubMed39617791

2024

Hypothermic oxygenated perfusion inhibits CLIP1-mediated TIRAP ubiquitination via TFPI2 to reduce ischemia‒reperfusion injury of the fatty liver.

Applications

Unspecified application

Species

Unspecified reactive species

Pengpeng Yue,Xiaoyan Lv,Hankun Cao,Yongkang Zou,Jian You,Jun Luo,Zhongshan Lu,Hao Chen,Zhongzhong Liu,Zibiao Zhong,Yan Xiong,Xiaoli Fan,Qifa Ye

Frontiers in pharmacology 15:1449985 PubMed39263577

2024

Protective effects of insulin on dry eye syndrome via TLR4/NF-κB pathway: based on network pharmacology and experiments validation.

Applications

Unspecified application

Species

Unspecified reactive species

Xiuxiu Yuan,Yu Zhang,Siyi Wang,Zhiyu Du

Frontiers in immunology 14:1150971 PubMed37090722

2023

A non-invasive strategy for suppressing asthmatic airway inflammation and remodeling: Inhalation of nebulized hypoxic hUCMSC-derived extracellular vesicles.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaowei Xu,Ying Wang,Xinkai Luo,Xuerong Gao,Weifeng Gu,Yongbin Ma,Lili Xu,Mengzhu Yu,Xi Liu,Jiameng Liu,Xuefeng Wang,Tingting Zheng,Chaoming Mao,Liyang Dong

Frontiers in microbiology 13:989183 PubMed36171749

2022

Toll-like receptor 2 signaling pathway activation contributes to a highly efficient inflammatory response in Japanese encephalitis virus-infected mouse microglial cells by proteomics.

Applications

Unspecified application

Species

Unspecified reactive species

Guanyu Zhao,Yan Gao,Jiaqi Zhang,He Zhang,Changzhan Xie,Fulong Nan,Sheng Feng,Zhuo Ha,Chenghui Li,Xiangyu Zhu,Zhuoxin Li,Ping Zhang,Ying Zhang,Huijun Lu,Ningyi Jin

Journal of leukocyte biology 112:383-393 PubMed35199885

2022

The phosphoinositide-3-kinase (PI3K)-delta inhibitor seletalisib impairs monocyte-derived dendritic cells maturation, APC function, and promotes their migration to CCR7 and CXCR4 ligands.

Applications

Unspecified application

Species

Unspecified reactive species

Fernanda Scopelliti,Laura Mercurio,Caterina Cattani,Valentina Dimartino,Cristina Albanesi,Gianfranco Costanzo,Concetta Mirisola,Stefania Madonna,Andrea Cavani

Frontiers in oncology 11:755212 PubMed34804944

2021

Establishment of a prognosis Prediction Model Based on Pyroptosis-Related Signatures Associated With the Immune Microenvironment and Molecular Heterogeneity in Clear Cell Renal Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Aimin Jiang,Jialin Meng,Yewei Bao,Anbang Wang,Wenliang Gong,Xinxin Gan,Jie Wang,Yi Bao,Zhenjie Wu,Juan Lu,Bing Liu,Linhui Wang

Cell death & disease 12:791 PubMed34385421

2021

Toll-like receptor 4 is a master regulator for colorectal cancer growth under high-fat diet by programming cancer metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Xianjing Hu,Sarwat Fatima,Minting Chen,Keyang Xu,Chunhua Huang,Rui-Hong Gong,Tao Su,Hoi Leong Xavier Wong,Zhaoxiang Bian,Hiu Yee Kwan

International journal of molecular sciences 22: PubMed34361111

2021

Cigarette Smoke Condensate Exposure Induces Receptor for Advanced Glycation End-Products (RAGE)-Dependent Sterile Inflammation in Amniotic Epithelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Helena Choltus,Régine Minet-Quinard,Corinne Belville,Julie Durif,Denis Gallot,Loic Blanchon,Vincent Sapin

American journal of translational research 13:24-37 PubMed33527006

2021

A naturally derived small molecule NDSM253 inhibits IKK1 to suppress inflammation response and promote bone healing after fracture.

Applications

Unspecified application

Species

Unspecified reactive species

Liqi Shen,Yun Xiao,Hui Xie,Hongbin Zhao,Tao Luo,Lin Liu,Xuekun Pan

Cell death & disease 11:374 PubMed32415087

2020

BIG1 controls macrophage pro-inflammatory responses through ARF3-mediated PI(4,5)P2 synthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Lixin Liu,Sulin Zhang,Yirui Wang,Weilian Bao,Yile Zhou,Wenzhen Dang,Xu Wang,Haidong Li,Xinyue Cao,Yan You,Hao Fang,Xiaoyan Shen
View all publications
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