Anti-TIPE2抗体(ab110389)
Key features and details
- Rabbit polyclonal to TIPE2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-TIPE2抗体
参阅全部 TIPE2 一抗 -
描述
兔多克隆抗体to TIPE2 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
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免疫原
Synthetic peptide corresponding to Human TIPE2 (internal sequence).
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阳性对照
- WB: Extracts from HuvEc cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol, 0.88% Sodium chloride -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab110389于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/1000. Predicted molecular weight: 21 kDa.
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| 说明 |
|---|
|
WB
1/500 - 1/1000. Predicted molecular weight: 21 kDa. |
靶标
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功能
Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. -
序列相似性
Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily. -
结构域
The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding. - Information by UniProt
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数据库链接
- Entrez Gene: 79626 Human
- Entrez Gene: 69769 Mouse
- Entrez Gene: 310663 Rat
- Omim: 612112 Human
- SwissProt: Q6P589 Human
- SwissProt: Q9D8Y7 Mouse
- SwissProt: Q6AYJ8 Rat
- Unigene: 709522 Human
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别名
- AW610835 antibody
- FLJ23467 antibody
- Inflammation factor 20 antibody
see all
图片
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Western blot - Anti-TIPE2 antibody (ab110389)All lanes : Anti-TIPE2 antibody (ab110389) at 1/500 dilution
Lane 1 : Extracts from HuvEc cells
Lane 2 : Extracts from HuvEc cells with blocking peptide at 10 µg
Lysates/proteins at 30 µg per lane.
Predicted band size: 21 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (12)
ab110389 被引用在 12 文献中.
- Gao K et al. Long noncoding RNA HOXA-AS2 ameliorates chronic intermittent hypoxia-induced lung inflammation by regulating miR-17-5p/tipe2 axis. Allergol Immunopathol (Madr) 51:36-44 (2023). PubMed: 36916086
- Zhang H et al. The Importance of Tumor Necrosis Factor-a-Induced Protein-8 Like-2 in the Pathogenesis of Cervical Cancer and Preeclampsia via Regulation of Cell Invasion. Tohoku J Exp Med 257:181-191 (2022). PubMed: 35418534
- Liu Y et al. TIPE2 inhibits the migration and invasion of endometrial cells by targeting ß-catenin to reverse epithelial-mesenchymal transition. Hum Reprod 35:1377-1390 (2020). PubMed: 32469403
- Gao K et al. Down-regulation of anti-inflammatory TIPE2 may aggravate adenoidal hypertrophy in children. FEBS Open Bio 10:761-766 (2020). PubMed: 32100476
- Zhao LL TIPE2 suppresses progression and tumorigenesis of the oral tongue squamous cell carcinoma by regulating FoxP3+ regulatory T cells. J Bioenerg Biomembr 52:279-289 (2020). PubMed: 32594290