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Anti-TIMP3抗体[MM0036-7D3] (ab61316)

Reviews (2) Submit a question
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP3 antibody [MM0036-7D3] (ab61316)

    Key features and details

    • Mouse monoclonal [MM0036-7D3] to TIMP3
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG1

    概述

    • 产品名称

      Anti-TIMP3抗体[MM0036-7D3]
      参阅全部 TIMP3 一抗

    • 描述

      小鼠单克隆抗体[MM0036-7D3] to TIMP3

    • 宿主

      Mouse

    • 经测试应用

      适用于: IHC-Pmore details

    • 种属反应性

      与反应: Human

    • 免疫原

      Recombinant full length protein (Human)

    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab61316于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    IHC-P (1)
    1/50 - 1/200.
    说明
    IHC-P
    1/50 - 1/200.

    靶标

    • 功能

      Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.

    • 疾病相关

      Defects in TIMP3 are the cause of Sorsby fundus dystrophy (SFD) [MIM:136900]. SFD is a rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.

    • 序列相似性

      Belongs to the protease inhibitor I35 (TIMP) family.
      Contains 1 NTR domain.

    • 细胞定位

      Secreted > extracellular space > extracellular matrix.
    • Information by UniProt

    • 数据库链接

      • 别名

        • HSMRK222 antibody
        • K222 antibody
        • K222TA2 antibody
        • Metalloproteinase inhibitor 3 antibody
        • MIG 5 protein antibody
        • MIG5 protein antibody
        • Protein MIG 5 antibody
        • Protein MIG-5 antibody
        • SFD antibody
        • Sorsby fundus dystrophy pseudoinflammatory antibody
        • TIMP 3 antibody
        • TIMP metallopeptidase inhibitor 3 antibody
        • TIMP-3 antibody
        • TIMP3 antibody
        • TIMP3_HUMAN antibody
        • Tissue Inhibitor of Metalloproteinase 3 antibody
        • Tissue inhibitor of metalloproteinases 3 antibody
        • Tissue inhibitor of metalloproteinases3 antibody
        see all

      图片

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP3 antibody [MM0036-7D3] (ab61316)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP3 antibody [MM0036-7D3] (ab61316)

        ab61316 at 1/200 dilution, staining TIMP3 in human placenta tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).

      文献 (0)

      发表研究结果有使用 ab61316？请让我们知道，以便我们可以引用本数据表中的参考文章。

      ab61316 尚未被引用在任何文献中。

      客户评价及客户问答

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      1-2 of 2 Abreviews or Q&A

      Immunocytochemistry/ Immunofluorescence abreview for Anti-TIMP3 antibody [MM0036-7D3]

       Below Average
      Abreviews
      abreview image
      Application
      Immunocytochemistry/ Immunofluorescence
      Sample
      Human Cell (hiPSC-RPE)
      Permeabilization
      Yes - 0.1% tritonX100
      Specification
      hiPSC-RPE
      Blocking step
      Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: RT°C
      Fixative
      Paraformaldehyde
      Read More
      The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

      Abcam user community

      Verified customer

      提交于 May 14 2018

      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-TIMP3 antibody [MM0036-7D3]

       Good
      Abreviews
      abreview image
      Application
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
      Blocking step
      Superblock as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 90% · Temperature: 25°C
      Antigen retrieval step
      Enzymatic
      Sample
      Pig Tissue sections (Suprarenal abdominal aorta)
      Specification
      Suprarenal abdominal aorta
      Permeabilization
      No
      Fixative
      Formaldehyde
      Read More
      The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

      Miss. Leng Lai Chan

      Verified customer

      提交于 May 01 2014

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