AB231176

Anti-TIMP2抗体

Name: TIMP2抗体 (ab231176)| Abcam中文官网
Brand: Abcam Limited
SKU: AB231176
Price: 4748 CNY
Availability: InStock

Anti-TIMP2 antibody

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(1 Publication)

Rabbit Polyclonal TIMP2 antibody. Suitable for WB and reacts with Recombinant fragment - Horse, Rat, Cow samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Horse TIMP2 aa 1 to C-terminus.

查看别名

Timp-2, Timp2, Metalloproteinase inhibitor 2, Tissue inhibitor of metalloproteinases 2, TIMP-2

4 Images

Supplier Data

Western blot - Anti-TIMP2 antibody (AB231176)

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Western blot - Anti-TIMP2 antibody (ab231176) at 2 µg/mL

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Rat placenta lysate

Predicted band size: 24 kDa

false

Supplier Data

Western blot - Anti-TIMP2 antibody (AB231176)

All lanes:

Western blot - Anti-TIMP2 antibody (ab231176) at 2 µg/mL

All lanes:

Recombinant horse TIMP2 protein

Predicted band size: 24 kDa

false

Supplier Data

Western blot - Anti-TIMP2 antibody (AB231176)

All lanes:

Western blot - Anti-TIMP2 antibody (ab231176) at 2 µg/mL

All lanes:

Cow cerebrum lysate

Predicted band size: 24 kDa

false

Supplier Data

Western blot - Anti-TIMP2 antibody (AB231176)

All lanes:

Western blot - Anti-TIMP2 antibody (ab231176) at 2 µg/mL

All lanes:

Cow kidney lysate

Predicted band size: 24 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Rat, Cow

应用

applications

免疫原

Recombinant Fragment Protein within Horse TIMP2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O77717

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment - Horse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab231176 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

存储溶液

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TIMP2 also known as Tissue Inhibitor of Metalloproteinases 2 mechanistically inhibits the activity of matrix metalloproteinases (MMPs). It binds to MMPs regulating the extracellular matrix's remodeling. The protein has a molecular mass of around 21 kDa. TIMP2 is expressed in various tissues including the brain liver and kidneys where it maintains a balance between matrix degradation and production.

Biological function summary

TIMP2 plays a significant role in tissue maintenance and repair by controlling extracellular matrix turnover. It forms complexes with MMPs such as MMP-2 inhibiting their proteolytic activities. The protein is also involved in cell proliferation and differentiation affecting processes like angiogenesis and wound healing. Its regulatory function aids in maintaining tissue homeostasis and preventing excessive matrix breakdown.

Pathways

TIMP2 is integral to the matrix metalloproteinase pathway and the regulation of endothelial cell migration. The protein interacts closely with other MMPs influencing their activation and modulation. Through these pathways TIMP2 holds an important position in cellular migration and signaling ensuring precise matrix remodeling in response to physiological needs.

TIMP2 has significant links with cancer and fibrosis. Dysregulation of TIMP2 expression or its imbalance with MMPs can contribute to tumor progression and metastasis due to uncontrolled matrix degradation. Additionally abnormal TIMP2 levels associate with fibrotic diseases where excessive tissue deposition occurs. TIMP2's interaction with proteins like MMP-9 and MMP-2 highlights its involvement in these pathological conditions.

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