Anti-TICAM2抗体(ab17221)
Key features and details
- Rabbit polyclonal to TICAM2
- Suitable for: ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-TICAM2抗体
参阅全部 TICAM2 一抗 -
描述
兔多克隆抗体to TICAM2 -
宿主
Rabbit -
经测试应用
适用于: ICC/IF, WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide (Human) (C terminal).
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阳性对照
- PC3 whole cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Ion Exchange Chromatography -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab17221于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF |
Use a concentration of 10 µg/ml.
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| WB |
Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 24 kDa.
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| 说明 |
|---|
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ICC/IF
Use a concentration of 10 µg/ml. |
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WB
Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 24 kDa. |
靶标
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功能
Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1. -
组织特异性
Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas. -
序列相似性
Contains 1 TIR domain. -
结构域
The TIR domain mediates the interaction with TRAF6. -
翻译后修饰
Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling. -
细胞定位
Cytoplasm. Golgi apparatus. Cell membrane. Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 100302736 Human
- Entrez Gene: 353376 Human
- Omim: 608321 Human
- SwissProt: Q86XR7 Human
- Unigene: 709120 Human
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别名
- Putative NF-kappa-B-activating protein 502 antibody
- TCAM2_HUMAN antibody
- TICAM-2 antibody
see all
图片
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Western blot - Anti-TICAM2 antibody (ab17221)Western Blot of PC-3 cell lysate labeling TICAM2 with Anti-TICAM2 antibody (ab17221) at 1µg/ml.
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Western blot - Anti-TICAM2 antibody (ab17221)Anti-TICAM2 antibody (ab17221) at 1 µg/ml + PC-3 cell lysate
Predicted band size: 24 kDa
Western blot using ab17221 at 1µ g/ml on PC-3 cell lysate. -
Immunocytochemistry/ Immunofluorescence - Anti-TICAM2 antibody (ab17221)ab17221 at 10µg/ml staining TICAM2 in Raji cells by ICC/IF
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab17221 被引用在 2 文献中.
- Alsaqer SF et al. Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis. Oncotarget 8:73372-73386 (2017). PubMed: 29088714
- Endo Y et al. Differences in PGE2 production between primary human monocytes and differentiated macrophages: role of IL-1ß and TRIF/IRF3. PLoS One 9:e98517 (2014). WB ; Human . PubMed: 24870145