AB203057

Anti-Thyroid Peroxidase/TPO 抗体

Name: Thyroid Peroxidase/TPO抗体 (ab203057)| Abcam中文官网
Brand: Abcam Limited
SKU: AB203057
Price: 4606 CNY
Availability: InStock
Rating: 4 (2 reviews)

Anti-Thyroid Peroxidase/TPO antibody

(2 Reviews)

(5 Publications)

Rabbit Polyclonal Thyroid Peroxidase/TPO antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Mouse Thyroid peroxidase aa 350-450 conjugated to Keyhole Limpet Haemocyanin.

查看别名

Thyroid peroxidase, TPO

1 Images

Flow Cyt

Supplier Data

Flow Cytometry - Anti-Thyroid Peroxidase/TPO antibody (AB203057)

MCF-7 cells were incubated in 5% BSA blocking buffer for 30 min at room temperature. Cells were then stained with Thyroid peroxidase Polyclonal Antibody (ab203057) at 1/100 dilution in blocking buffer and incubated for 30 min at room temperature, washed twice with 2% BSA in PBS, followed by secondary antibody incubation for 40 min at room temperature. Acquisitions of 20,000 events were performed. Cells stained with primary antibody (green), and isotype control (orange).

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

Flow Cyt, WB

applications

免疫原

Synthetic Peptide within Mouse Thyroid peroxidase aa 350-450 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P35419

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Thyroid Peroxidase (TPO) also known as thyroperoxidase is an enzyme with a molecular mass of around 105 kDa. It is expressed in the thyroid gland's follicular cells. TPO plays a mechanical role in the synthesis of thyroid hormones by catalyzing iodination and coupling reactions needed to produce triiodothyronine (T3) and thyroxine (T4). These hormones are essential for regulating metabolism growth and development. The activity of TPO is an important step in thyroid hormone production.

Biological function summary

TPO participates in the thyroid's hormone biosynthesis pathway. It forms a part of the multi-enzyme complex that includes thyroglobulin and iodide. The enzyme facilitates the iodination of tyrosine residues on thyroglobulin and the coupling of iodotyrosines important for creating active thyroid hormones. TPO's enzymatic function is important for maintaining appropriate levels of circulating T3 and T4 impacting various physiological processes in the body.

Pathways

TPO contributes to the thyroid hormone synthesis pathway which is a critical pathway for metabolic regulation. It works in close association with other proteins such as thyroglobulin and sodium/iodide symporter (NIS) to ensure efficient thyroid hormone production. TPO's involvement in these pathways indicates its importance in the endocrine system's normal function and homeostasis.

TPO is often associated with autoimmune thyroid diseases like Hashimoto's thyroiditis and Graves' disease. High TPO antibodies such as anti-TPO antibodies are commonly detected in these conditions indicating an autoimmune response against the thyroid. The presence of high anti-thyroid peroxidase antibodies can lead to the destruction of thyroid tissue often resulting in hypothyroidism. TPO's connection to these diseases highlights its role in autoimmune conditions affecting thyroid function.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

See full target information Thyroid peroxidase

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Clinical and translational medicine 14:e1694 PubMed38797942

2024

Targeting miR-31 represses tumourigenesis and dedifferentiation of BRAF-associated thyroid carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Peitao Zhang,Lizhao Guan,Wei Sun,Yu Zhang,Yaying Du,Shukai Yuan,Xiaolong Cao,Zhengquan Yu,Qiang Jia,Xiangqian Zheng,Zhaowei Meng,Xingrui Li,Li Zhao

Environmental toxicology 37:2924-2936 PubMed36005737

2022

Di(2-ethylhexyl) phthalate induced thyroid toxicity via endoplasmic reticulum stress: In vivo and in vitro study.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Xu,Tianyang Zhao,Hyonju Ri,Jiaming Ye,Weisen Zhao,Yuezhu Zhang,Lin Ye

Frontiers in immunology 12:637659 PubMed33767707

2021

Activation of Toll-Like Receptor 7 Signaling Pathway in Primary Sjögren's Syndrome-Associated Thrombocytopenia.

Applications

Unspecified application

Species

Unspecified reactive species

Shuo Zhang,Jingge Qu,Li Wang,Mengtao Li,Dong Xu,Yan Zhao,Fengchun Zhang,Xiaofeng Zeng

Molecular medicine reports 23: PubMed33649816

2021

Novel insights into di‑(2‑ethylhexyl)phthalate activation: Implications for the hypothalamus‑pituitary‑thyroid axis.

Applications

Unspecified application

Species

Unspecified reactive species

Haoyu Wu,Wanying Zhang,Yunbo Zhang,Zhen Kang,Xinxiunan Miao,Xiaolin Na

Scientific reports 8:4004 PubMed29507327

2018

Generation and characterization of a hypothyroidism rat model with truncated thyroid stimulating hormone receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Jianqiang Yang,Ning Yi,Junhui Zhang,Wen He,Di He,Wanwan Wu,Shuyang Xu,Feng Li,Guoping Fan,Xianmin Zhu,Zhigang Xue,Wensheng Zhou

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Thyroid Peroxidase/TPO 抗体

Anti-Thyroid Peroxidase/TPO antibody

Flow Cytometry - Anti-Thyroid Peroxidase/TPO antibody (AB203057)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

反应性数据

性能和储存信息

形式

纯化工艺

存储溶液

运输条件

推荐的短期储存时间

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (5)

Abcam Product Promise

Anti-Thyroid Peroxidase/TPO 抗体

Anti-Thyroid Peroxidase/TPO antibody

Flow Cytometry - Anti-Thyroid Peroxidase/TPO antibody (AB203057)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

替代产品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

搭配使用产品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

反应性数据

性能和储存信息

形式

纯化工艺

存储溶液

运输条件

推荐的短期储存时间

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (5)

Abcam Product Promise