AB167650

Anti-Thymosin beta 4抗体

Name: Thymosin beta 4抗体 (ab167650)| Abcam中文官网
Brand: Abcam Limited
SKU: AB167650
Price: 4781 CNY
Availability: InStock

Anti-Thymosin beta 4 antibody

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(7 Publications)

Mouse Polyclonal Thymosin beta 4 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TMSB4X.

查看别名

TB4X, THYB4, TMSB4, TMSB4X, Thymosin beta-4, T beta-4, Fx

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-Thymosin beta 4 antibody (AB167650)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Thymosin beta 4 antibody (AB167650)

Immunofluorescent analysis of HeLa cells labeling Thymosin beta 4 with ab167650 at 10 µg/ml.

Unknown

Western blot - Anti-Thymosin beta 4 antibody (AB167650)

All lanes:

Western blot - Anti-Thymosin beta 4 antibody (ab167650) at 1 µg/mL

Lane 1:

Thymosin beta 4 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG HRP at 1/2500 dilution

Predicted band size: 12 kDa,5 kDa

false

关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, ICC/IF

applications

免疫原

Recombinant Full Length Protein corresponding to Human TMSB4X.

P62328

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Thymosin beta 4 is a small actin-binding peptide known for its role in the regulation of actin polymerization and depolymerization. Sometimes called Tβ4 or beta thymosin this peptide has a mass of approximately 5 kDa. It is widely expressed in various tissues especially in wound sites circulatory system and the central nervous system. The peptide consists of 43 amino acids and its structure allows it to sequester actin monomers influencing the cytoskeleton dynamics within cells.

Biological function summary

Thymosin beta 4 influences several cellular processes including cell migration proliferation and differentiation. It is not part of a large complex but directly interacts with actin to modulate its behavior. Through its regulation of actin filament formation it plays a significant role in wound healing tissue regeneration and inflammatory responses. Furthermore it contributes to the migration of endothelial cells highlighting its importance in angiogenesis.

Pathways

Thymosin beta 4 contributes significantly to cell motility and the vascular endothelial growth factor (VEGF) pathway. It interacts with the protein profilin in the regulation of actin dynamics impacting cellular processes like cell movement and angiogenesis. By influencing these pathways Thymosin beta 4 aids in the body's repair mechanisms providing cellular structural support under varying physiological conditions.

Thymosin beta 4 is associated with cardiovascular diseases and fibrotic disorders. It has a potential protective effect in ischemic heart disease where it contributes to heart repair by modulating actin and promoting endothelial cell migration. In fibrosis its regulatory effects on actin filaments may impact the excessive tissue scarring. Thymosin beta 4 also interacts with proteins like beta-adrenoreceptors during cardiovascular stress responses demonstrating its multi-faceted role in health and disease.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Plays an important role in the organization of the cytoskeleton (PubMed : 10848969, PubMed : 1999398). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed : 10848969, PubMed : 1999398).. Hemoregulatory peptide AcSDKP. Potent inhibitor of bone marrow derived stem cell differentiation (PubMed : 7694679). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity).

See full target information TMSB4X

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文献 (7)

Recent publications for all applications. Explore the full list and refine your search

Nature cardiovascular research 3:283-300 PubMed38510108

2024

YAP induces a neonatal-like pro-renewal niche in the adult heart.

Applications

Unspecified application

Species

Unspecified reactive species

Rich Gang Li,Xiao Li,Yuka Morikawa,Francisco J Grisanti-Canozo,Fansen Meng,Chang-Ru Tsai,Yi Zhao,Lin Liu,Jong Kim,Bing Xie,Elzbieta Klysik,Shijie Liu,Md Abul Hassan Samee,James F Martin

Cardiovascular therapeutics 2022:1308651 PubMed35712678

2022

Thymosin 4 Protects against Cardiac Damage and Subsequent Cardiac Fibrosis in Mice with Myocardial Infarction.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Wang,Yajuan He,Naijuan Yao,Litao Ruan,Zhen Tian

Bioengineered 12:7104-7118 PubMed34546850

2021

Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Sun,Yan Wei,Junli Wang

Inflammation 45:59-73 PubMed34414534

2021

Thymosin β4 Suppresses LPS-Induced Murine Lung Fibrosis by Attenuating Oxidative Injury and Alleviating Inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Tian,Naijuan Yao,Fei Wang,Litao Ruan

Journal of neuroinflammation 18:146 PubMed34183019

2021

Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice.

Applications

Unspecified application

Species

Unspecified reactive species

Meng Wang,Li-Rong Feng,Zi-Long Li,Kai-Ge Ma,Ke-Wei Chang,Xin-Lin Chen,Peng-Bo Yang,Sheng-Feng Ji,Yan-Bing Ma,Hua Han,John Bosco Ruganzua,Wei-Na Yang,Yi-Hua Qian

Frontiers in cell and developmental biology 9:684819 PubMed34222253

2021

Cytoplasmic Localization Isoform of Cyclin Y Enhanced the Metastatic Ability of Lung Cancer Regulating Tropomyosin 4.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoting Zhao,Mei Jiang,Yu Teng,Jie Li,Zhefeng Li,Wende Hao,Hongyu Zhao,Chenghong Yin,Wentao Yue

International immunopharmacology 82:106354 PubMed32143008

2020

5-HTR alleviates Aβ-induced cognitive decline and neuroinflammation through crosstalk with NF-κB pathway in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Meng Wang,Hang-Fan Zong,Ke-Wei Chang,Hua Han,Mohammad Yasir Rizvi,Saema Iffat Neha,Zhi-Yi Li,Wei-Na Yang,Yi-Hua Qian

View all publications

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Anti-Thymosin beta 4抗体

Anti-Thymosin beta 4 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Thymosin beta 4 antibody (AB167650)

Western blot - Anti-Thymosin beta 4 antibody (AB167650)