AB243031

Anti-THSD7A抗体[CL3778]

Name: THSD7A抗体[CL3778] (ab243031)| Abcam中文官网
Brand: Abcam Limited
SKU: AB243031
Price: 5814 CNY
Availability: InStock

Anti-THSD7A antibody [CL3778]

Be the first to review this product! Submit a review

(2 Publications)

Mouse Monoclonal THSD7A antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human THSD7A aa 200-400.

查看别名

KIAA0960, THSD7A, Thrombospondin type-1 domain-containing protein 7A

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

Formalin-fixed, paraffin-embedded human cerebral cortex tissue stained for THSD7A with ab243031 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

Formalin-fixed, paraffin-embedded human kidney tissue stained for THSD7A with ab243031 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

Negative control - Formalin-fixed, paraffin-embedded human skeletal muscle tissue stained for THSD7A with ab243031 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

Formalin-fixed, paraffin-embedded human testis tissue stained for THSD7A with ab243031 at a 1/500 dilution in immunohistochemical analysis.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

CL3778

亚型

IgG1

不含载体蛋白

反应种属

Human

应用

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human THSD7A aa 200-400. The exact immunogen used to generate this antibody is proprietary information.

Q9UPZ6

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

纯化说明

Purified from TCS.

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

THSD7A also known as Thrombospondin Type-1 Domain Containing Protein 7A is a glycoprotein with a mass of approximately 250 kDa. The glycoprotein is expressed mainly in the kidneys and brain and to some extent in the placenta and lungs. This expression pattern suggests its potential role in the vascular system and nervous tissues. THSD7A is localized at endothelial cells where it is thought to interact with the extracellular matrix.

Biological function summary

THSD7A influences cell adhesion and migration processes. It plays a significant role in angiogenesis promoting the formation and maintenance of blood vessels. This protein often partners with integrins forming a complex that modulates various cellular interactions essential for vessel stability and permeability. THSD7A's involvement in the developing circulatory system signifies its importance in embryonic growth and development.

Pathways

This protein intersects the angiogenesis and cell adhesion pathways. Within these contexts THSD7A interacts with other proteins such as vascular endothelial growth factor (VEGF) and integrins which are critical for the angiogenesis process. These interactions facilitate proper cell signaling that ensures blood vessel formation and repair stressing its functional significance in vascular biology.

THSD7A has links with membranous nephropathy an autoimmune kidney condition. Autoantibodies against THSD7A are found in a subset of patients with this disease linking it directly to disease pathology. Additionally given its role in angiogenesis abnormalities in THSD7A expression or function may also relate to cancer progression where angiogenic imbalance plays a pivotal role. Understanding THSD7A's connection with VEGF during these disease states highlights it as an important target for therapeutic interventions.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Thrombospondin type-1 domain-containing protein 7A. Plays a role in actin cytoskeleton rearrangement.. Thrombospondin type-1 domain-containing protein 7A, soluble form. The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.

See full target information THSD7A

style

left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

BMC gastroenterology 25:179 PubMed40098080

2025

THSD7A as a novel prognostic factor for colorectal carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Oktay Halit Aktepe,Olcay Kurtulan,Pinar Ezgi Dama,Ahmet Melih Arslan,Elif Atag,Meral Uner,Berfu Korucu,Aziz Karaoglu,Suayib Yalcin

Biomacromolecules 25:6485-6502 PubMed39214607

2024

Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Martina Doubková,Jarmila Knitlová,David Vondrášek,Adam Eckhardt,Tomáš Novotný,Martin Ošt'ádal,Elena Filová,Lucie Bačáková

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-THSD7A抗体[CL3778]

Anti-THSD7A antibody [CL3778]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

免疫原