Anti-TGFBI抗体(ab122975)
Key features and details
- Goat polyclonal to TGFBI
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-TGFBI抗体
参阅全部 TGFBI 一抗 -
描述
山羊多克隆抗体to TGFBI -
宿主
Goat -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Dog
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免疫原
Synthetic peptide from an internal region of Human TGFBI, conjugated to KLH
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阳性对照
- Human Kidney, Renal Duct Human Kidney lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab122975于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (2) |
Use a concentration of 0.2 - 0.5 µg/ml. Predicted molecular weight: 75 kDa.
|
| IHC-P |
Use a concentration of 3.75 µg/ml.
|
| 说明 |
|---|
|
WB
Use a concentration of 0.2 - 0.5 µg/ml. Predicted molecular weight: 75 kDa. |
|
IHC-P
Use a concentration of 3.75 µg/ml. |
靶标
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功能
Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. -
组织特异性
Highly expressed in the corneal epithelium. -
疾病相关
Defects in TGFBI are the cause of epithelial basement membrane corneal dystrophy (EBMD) [MIM:121820]; also known as Cogan corneal dystrophy or map-dot-fingerprint type corneal dystrophy. EBMD is a bilateral anterior corneal dystrophy characterized by grayish epithelial fingerprint lines, geographic map-like lines, and dots (or microcysts) on slit-lamp examination. Pathologic studies show abnormal, redundant basement membrane and intraepithelial lacunae filled with cellular debris. Although this disorder usually is not considered to be inherited, families with autosomal dominant inheritance have been identified.
Defects in TGFBI are the cause of corneal dystrophy Groenouw type 1 (CDGG1) [MIM:121900]; also known as corneal dystrophy granular type. Inheritance is autosomal dominant. Corneal dystrophies show progressive opacification of the cornea leading to severe visual handicap.
Defects in TGFBI are the cause of corneal dystrophy lattice type 1 (CDL1) [MIM:122200]. Inheritance is autosomal dominant.
Defects in TGFBI are a cause of corneal dystrophy Thiel-Behnke type (CDTB) [MIM:602082]; also known as corneal dystrophy of Bowman layer type 2 (CDB2).
Defects in TGFBI are the cause of Reis-Buecklers corneal dystrophy (CDRB) [MIM:608470]; also known as corneal dystrophy of Bowman layer type 1 (CDB1).
Defects in TGFBI are the cause of lattice corneal dystrophy type 3A (CDL3A) [MIM:608471]. CDL3A clinically resembles to lattice corneal dystrophy type 3, but differs in that its age of onset is 70 to 90 years. It has an autosomal dominant inheritance pattern.
Defects in TGFBI are the cause of Avellino corneal dystrophy (ACD) [MIM:607541]. ACD could be considered a variant of granular dystrophy with a significant amyloidogenic tendency. Inheritance is autosomal dominant. -
序列相似性
Contains 1 EMI domain.
Contains 4 FAS1 domains. -
翻译后修饰
Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. -
细胞定位
Secreted > extracellular space > extracellular matrix. May be associated both with microfibrils and with the cell surface. - Information by UniProt
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数据库链接
- Entrez Gene: 7045 Human
- Entrez Gene: 21810 Mouse
- Entrez Gene: 116487 Rat
- Omim: 601692 Human
- SwissProt: Q15582 Human
- SwissProt: P82198 Mouse
- Unigene: 369397 Human
- Unigene: 14455 Mouse
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别名
- RGD containing collagen associated protein antibody
- AI181842 antibody
- AI747162 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TGFBI antibody (ab122975)Immunohistochemistry of Formalin-Fixed, Paraffin-Embedded Human Kidney, Renal Duct, with ab122975 at 3.75ug/ml.
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Western blot - Anti-TGFBI antibody (ab122975)Anti-TGFBI antibody (ab122975) at 0.3 µg/ml + Human Kidney lysate at 35 µg/ml
Developed using the ECL technique.
Predicted band size: 75 kDa
Exposure time: 1 hour
数据表及文件
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Datasheet download
文献 (0)
ab122975 尚未被引用在任何文献中。
