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AB3970

Anti-Tenascin C 抗体 [T2H5]

Anti-Tenascin C antibody [T2H5]

0

(1 Review)

|

(19 Publications)

Mouse Monoclonal Tenascin C antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 19 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human TNC.

查看别名

HXB, TNC, Tenascin, TN, Cytotactin, GMEM, GP 150-225, Glioma-associated-extracellular matrix antigen, Hexabrachion, JI, Myotendinous antigen, Neuronectin, Tenascin-C, TN-C

2 Images
Western blot - Anti-Tenascin C antibody [T2H5] (AB3970)
  • WB

Supplier Data

Western blot - Anti-Tenascin C antibody [T2H5] (AB3970)

All lanes:

Western blot - Anti-Tenascin C antibody [T2H5] (ab3970) at 2 µg/mL

Lane 1:

U87-MG cell lysates, non-reduced

Lane 2:

Jurkat cell lysates, non-reduced

Lane 3:

U87-MG cell lysates, reduced

Lane 4:

Jurkat cell lysates, reduced

Secondary

All lanes:

IRDye800-conjugated anti-mouse secondary antibody

Predicted band size: 241 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tenascin C antibody [T2H5] (AB3970)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tenascin C antibody [T2H5] (AB3970)

ab3970 staining paraffin embedded tonsil tissue sections.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

T2H5

亚型

IgG1

轻链类型

unknown

不含载体蛋白

No

反应种属

Human

应用

WB, IHC-P

applications

免疫原

Native Full Length Protein corresponding to Human TNC.

P24821

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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您可能对以下产品感兴趣:

AB277081

Human Tenascin C ELISA Kit

0

0 Reviews

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为什么推荐这个？

我们推荐这个产品，因为它经常被用于相同的实验或相关的研究。

我们建议您务必查阅产品说明书，以确认其是否符合您的实验需求；若有疑问，也可联系我们的技术团队获取协助。

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产品详情

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
纯化说明
Purified from hybridoma culture supernatant. Purity >95% by SDS-PAGE.
存储溶液
pH: 8 Preservative: 0.097% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Tenascin C also known as hexabrachion is an extracellular matrix glycoprotein with a mass of approximately 220-300 kDa depending on post-translational modifications. It shows high expression in areas undergoing tissue remodeling such as embryonic tissues wounds and tumors. It consists of repeating structural elements including epidermal growth factor-like repeats and fibronectin type III domains which facilitate its function in the context of tissue dynamics.
Biological function summary

The large hexamer known as Tenascin C plays a significant role in modulating cell adhesion migration and proliferation especially during developmental processes and injury responses. It incorporates into the existing extracellular matrix as a loose network which provides elasticity and supports cellular activities. This feature allows Tenascin C to interact with other matrix molecules and cell surface receptors to regulate tissue morphogenesis.

Pathways

Tenascin C actively participates in the Wnt and TGF-beta signaling pathways important for controlling cellular behavior in development and regeneration. It associates with integrins and glycoproteins to influence cell responses to signaling events in these pathways. By modulating these interactions Tenascin C can impact processes such as epithelial-to-mesenchymal transition and angiogenesis affecting tissue architecture and function.

Tenascin C exhibits a strong connection to cancer progression and chronic inflammatory conditions such as rheumatoid arthritis. Its levels rise in tumors and inflamed tissues where it interacts with other matrix components and cytokines like interleukin-6 (IL-6). These interactions contribute to a microenvironment that promotes tumor growth and persistence of inflammation highlighting its role in the pathophysiology of these diseases.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed : 19884327).
See full target information TNC
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文献 (19)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 13:10401 PubMed37369713

2023

Shotgun proteomics identification of proteins expressed in the Descemet's membrane of patients with Fuchs endothelial corneal dystrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Tatsuya Nakagawa,Naoki Okumura,Masaya Ikegawa,Yumiko Toyama,Takashi Nirasawa,Frederic Mascarelli,Hanielle Vaitinadapoule,Ines Aouimeur,Zhiguo He,Philippe Gain,Gilles Thuret,Noriko Koizumi

Scientific reports 12:4462 PubMed35292718

2022

The possible role of hypoxia in the affected tissue of relapsed clubfoot.

Applications

Unspecified application

Species

Unspecified reactive species

Tomas Novotny,Adam Eckhardt,Martina Doubkova,Jarmila Knitlova,David Vondrasek,Eliska Vanaskova,Martin Ostadal,Jiri Uhlik,Lucie Bacakova,Jana Musilkova

Biomaterials 279:121204 PubMed34736146

2021

Integration and functional performance of a decellularised porcine superflexor tendon graft in an ovine model of anterior cruciate ligament reconstruction.

Applications

Unspecified application

Species

Unspecified reactive species

Jennifer Helen Edwards,Gemma Louise Jones,Anthony Herbert,John Fisher,Eileen Ingham

Cell research : PubMed32839552

2020

Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Shen'ao Zhou,Wei Zhang,Gaihong Cai,Yingzhe Ding,Caixia Wei,Sheng Li,Yu Yang,Jie Qin,Dan Liu,Hao Zhang,Xiexiang Shao,Jianhua Wang,Hongye Wang,Wenjun Yang,Huating Wang,She Chen,Ping Hu,Liming Sun

JCI insight 5: PubMed32045383

2020

Fibroblast subtypes define a metastatic matrisome in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Heather M Brechbuhl,Alexander S Barrett,Etana Kopin,Jaime C Hagen,Amy L Han,Austin E Gillen,Jessica Finlay-Schultz,Diana M Cittelly,Philip Owens,Kathryn B Horwitz,Carol A Sartorius,Kirk Hansen,Peter Kabos

Developmental cell 50:462-477.e5 PubMed31204172

2019

Id1 Stabilizes Epiblast Identity by Sensing Delays in Nodal Activation and Adjusting the Timing of Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Mattias Malaguti,Rosa Portero Migueles,Guillaume Blin,Chia-Yi Lin,Sally Lowell

BMC pulmonary medicine 18:63 PubMed29703175

2018

Anti-fibrotic effects of pirfenidone and rapamycin in primary IPF fibroblasts and human alveolar epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

M Molina-Molina,C Machahua-Huamani,V Vicens-Zygmunt,R Llatjós,I Escobar,E Sala-Llinas,P Luburich-Hernaiz,J Dorca,A Montes-Worboys

Nature communications 8:1271 PubMed29097665

2017

RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain.

Applications

Unspecified application

Species

Unspecified reactive species

Pamela Valnegri,Ju Huang,Tomoko Yamada,Yue Yang,Luis A Mejia,Ha Y Cho,Anna Oldenborg,Azad Bonni

Journal of cellular biochemistry 116:2858-69 PubMed26015264

2015

Insulin-Like Growth Factor II (IGF-II) Inhibits IL-1β-Induced Cartilage Matrix Loss and Promotes Cartilage Integrity in Experimental Osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Tomoya Uchimura,Andrea T Foote,Eric L Smith,Elizabeth G Matzkin,Li Zeng

Neurobiology of disease 78:57-67 PubMed25843669

2015

A variant of Nesprin1 giant devoid of KASH domain underlies the molecular etiology of autosomal recessive cerebellar ataxia type I.

Applications

Unspecified application

Species

Unspecified reactive species

David Razafsky,Didier Hodzic
View all publications
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