AB212463

Anti-Tenascin C抗体[SPM319] - BSA and Azide free

Name: Tenascin C抗体[SPM319] - BSA and Azide free (ab212463)| Abcam中文官网
Brand: Abcam Limited
SKU: AB212463
Price: 9609 CNY
Availability: InStock

Anti-Tenascin C antibody [SPM319] - BSA and Azide free

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(1 Publication)

Mouse Monoclonal Tenascin C antibody. Carrier free. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Tissue preparation containing TNC protein.

查看别名

HXB, TNC, Tenascin, TN, Cytotactin, GMEM, GP 150-225, Glioma-associated-extracellular matrix antigen, Hexabrachion, JI, Myotendinous antigen, Neuronectin, Tenascin-C, TN-C

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tenascin C antibody [SPM319] - BSA and Azide free (AB212463)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tenascin C antibody [SPM319] - BSA and Azide free (AB212463)

Immunohistochemical analysis of formalin fixed, paraffin embedded Human lung carcinoma tissue labeling Tenascin C with ab212463 at 4 μg/ml.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

SPM319

亚型

IgG1

轻链类型

kappa

不含载体蛋白

Yes

反应种属

Human

应用

IHC-P

applications

免疫原

Tissue preparation containing TNC protein. The exact immunogen used to generate this antibody is proprietary information.

P24821

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2-4 µg/mL", "IHCP-species-notes": "<p>for 30 minutes at room temperature.</p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." }, "Rat": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p>for 30 minutes at room temperature.</p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A/G

存储溶液

pH: 7.2 - 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Tenascin C also known as hexabrachion is an extracellular matrix glycoprotein with a mass of approximately 220-300 kDa depending on post-translational modifications. It shows high expression in areas undergoing tissue remodeling such as embryonic tissues wounds and tumors. It consists of repeating structural elements including epidermal growth factor-like repeats and fibronectin type III domains which facilitate its function in the context of tissue dynamics.

Biological function summary

The large hexamer known as Tenascin C plays a significant role in modulating cell adhesion migration and proliferation especially during developmental processes and injury responses. It incorporates into the existing extracellular matrix as a loose network which provides elasticity and supports cellular activities. This feature allows Tenascin C to interact with other matrix molecules and cell surface receptors to regulate tissue morphogenesis.

Pathways

Tenascin C actively participates in the Wnt and TGF-beta signaling pathways important for controlling cellular behavior in development and regeneration. It associates with integrins and glycoproteins to influence cell responses to signaling events in these pathways. By modulating these interactions Tenascin C can impact processes such as epithelial-to-mesenchymal transition and angiogenesis affecting tissue architecture and function.

Tenascin C exhibits a strong connection to cancer progression and chronic inflammatory conditions such as rheumatoid arthritis. Its levels rise in tumors and inflamed tissues where it interacts with other matrix components and cytokines like interleukin-6 (IL-6). These interactions contribute to a microenvironment that promotes tumor growth and persistence of inflammation highlighting its role in the pathophysiology of these diseases.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed : 19884327).

See full target information TNC

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

eLife 11: PubMed35507395

2022

Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Edward Fielder,Tengfei Wan,Ghazaleh Alimohammadiha,Abbas Ishaq,Evon Low,B Melanie Weigand,George Kelly,Craig Parker,Brigid Griffin,Diana Jurk,Viktor I Korolchuk,Thomas von Zglinicki,Satomi Miwa

View all publications

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Abcam Product Promise

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For licensing inquiries, please contact partnerships@abcam.com

Anti-Tenascin C抗体[SPM319] - BSA and Azide free

Anti-Tenascin C antibody [SPM319] - BSA and Azide free

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tenascin C antibody [SPM319] - BSA and Azide free (AB212463)

关键信息

宿主种属

克隆

克隆号

亚型

轻链类型

不含载体蛋白

反应种属

应用

免疫原