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AB210773

Anti-Telethonin抗体

Anti-Telethonin antibody

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(3 Publications)

Rabbit Polyclonal Telethonin antibody. Suitable for WB, ICC/IF and reacts with Rat, Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TCAP.

查看别名

Telethonin, Titin cap protein, TCAP

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-Telethonin antibody (AB210773)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Telethonin antibody (AB210773)

Immunofluorescent analysis of HeLa cells labeling Telethonin with ab210773 at 1/10 dilution (red). Blue : DAPI for nuclear staining.

Western blot - Anti-Telethonin antibody (AB210773)
  • WB

Supplier Data

Western blot - Anti-Telethonin antibody (AB210773)

All lanes:

Western blot - Anti-Telethonin antibody (ab210773) at 1/500 dilution

Lane 1:

Mouse heart extract

Lane 2:

Mouse skeletal muscle extract

Lane 3:

Rat heart extract

Lanes 4 - 5:

Rat skeletal muscle extract

Predicted band size: 19 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Mouse, Rat, Human

应用

WB, ICC/IF

applications

免疫原

Recombinant Full Length Protein corresponding to Human TCAP.

O15273

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替代产品

Primary Antibodies

AB228582

Anti-Telethonin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Telethonin antibody (AB228582)

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  • 0
Primary Antibodies

AB121868

Anti-Telethonin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Telethonin antibody (AB121868)

  • 0
  • 0
Primary Antibodies

AB133646

Anti-Telethonin antibody [EPR8375]

RabMAb|Recombinant|Trial Size

Western blot - Anti-Telethonin antibody [EPR8375] (AB133646)

  • 5
  • 2

搭配使用产品

Primary Antibodies

AB307446

Anti-Titin antibody [EPR26167-75]

BOND RX™ Validated|20ul selling size|Recombinant|Advanced Validation|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Titin antibody [EPR26167-75] (AB307446)

  • 0
  • 0
Primary Antibodies

AB109535

Anti-TDP43 antibody [EPR5810]

20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant

Immunohistochemistry (Frozen sections) - Anti-TDP43 antibody [EPR5810] (AB109535)

  • 5
  • 1
Primary Antibodies

AB47124

Anti-Bag3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Bag3 antibody (AB47124)

  • 5
  • 1
Primary Antibodies

AB223378

Anti-Ubiquitin antibody [5B9-B3]

Immunocytochemistry/ Immunofluorescence - Anti-Ubiquitin antibody [5B9-B3] (AB223378)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/10 - 1/100", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Telethonin also known as Tcap is a small protein with a molecular mass of approximately 19 kDa. It is an important component of the sarcomere in striated muscle cells primarily expressed in the heart and skeletal muscles. Telethonin resides at the Z-disc of the sarcomere where it interacts with titin one of the largest known proteins to maintain the structural integrity and elasticity of muscle tissues. This protein supports the mechanical stability of muscle fibers during contraction and relaxation by acting as a molecular spring.
Biological function summary

The function of telethonin expands beyond simple structural support. It acts as part of the protein complex at the Z-disc important for maintaining sarcomere architecture. This complex involves interactions not only with titin but also with other structural proteins such as actin and myotilin. Telethonin's presence helps coordinate the assembly and maintenance of the Z-disc contributing to muscle strength and resilience. It also plays a role in signaling pathways that regulate muscle protein gene expression and response to mechanical stress.

Pathways

Telethonin integrates into several significant signaling cascades. One major pathway involves the titin-telethonin interaction as part of the mechanical signaling responsible for muscle function and adaptation. Through its involvement with titin telethonin influences pathways linked to muscle hypertrophy and atrophy as well as sarcomere organization. Furthermore telethonin associates with signaling proteins like myostatin an important regulator of muscle growth modulating muscle size and adaptation to workload changes.

Telethonin's malfunction often shows links with cardiomyopathies and muscular dystrophies. Mutations in the telethonin gene are associated with limb-girdle muscular dystrophy type 2G a condition where muscle weakness and degeneration occur due to defects in the muscle fiber structure. Moreover telethonin's interaction with titin connects it to dilated cardiomyopathy a condition where the heart weakens and enlarges impairing its ability to pump effectively. Understanding telethonin’s role provides insights into these muscle-related diseases and offers potential therapeutic targets for intervention.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
See full target information TCAP
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 24: PubMed36835551

2023

Changes in the Mechanical Properties of Fast and Slow Skeletal Muscle after 7 and 21 Days of Restricted Activity in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Sergey A Tyganov,Svetlana P Belova,Olga V Turtikova,Ivan M Vikhlyantsev,Tatiana L Nemirovskaya,Boris S Shenkman

Pflugers Archiv : European journal of physiology 474:1171-1183 PubMed35931829

2022

Calpain-dependent degradation of cytoskeletal proteins as a key mechanism for a reduction in intrinsic passive stiffness of unloaded rat postural muscle.

Applications

Unspecified application

Species

Unspecified reactive species

I Y Melnikov,Sergey A Tyganov,K A Sharlo,A D Ulanova,I M Vikhlyantsev,T M Mirzoev,B S Shenkman

Frontiers in pharmacology 13:819826 PubMed35645824

2022

Protects Against Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Restoring the Intestinal Mucosal Barrier and Modulating the Oncostatin M/Oncostatin M Receptor Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yao Li,Xu Yang,Jia-Ni Yuan,Rui Lin,Yun-Yuan Tian,Yu-Xin Li,Yan Zhang,Xu-Fang Wang,Yan-Hua Xie,Si-Wang Wang,Xiao-Hui Zheng
View all publications
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