Anti-TEAD4抗体(ab97460)
Key features and details
- Rabbit polyclonal to TEAD4
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-TEAD4抗体
参阅全部 TEAD4 一抗 -
描述
兔多克隆抗体to TEAD4 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Pig -
免疫原
Recombinant protein fragment corresponding to a region within amino acids 1 - 230 of Human TEAD4 (NP_003204).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 78% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab97460于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 48 kDa.
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IHC-P |
1/100 - 1/500.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 48 kDa. |
IHC-P
1/100 - 1/500. |
靶标
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功能
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. -
组织特异性
Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. -
序列相似性
Contains 1 TEA DNA-binding domain. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 7004 Human
- Entrez Gene: 21679 Mouse
- Entrez Gene: 100152085 Pig
- Omim: 601714 Human
- SwissProt: Q15561 Human
- SwissProt: Q62296 Mouse
- Unigene: 94865 Human
- Unigene: 14774 Mouse
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别名
- EFTR 2 antibody
- EFTR2 antibody
- hRTEF 1B antibody
see all
图片
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Anti-TEAD4 antibody (ab97460) at 1/1000 dilution + HepG2 cell lysate at 30 µg
Predicted band size: 48 kDa
10% SDS PAGE -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TEAD4 antibody (ab97460)
ab97460, at 1/500 dilution, staining TEAD4 in a paraffin-embedded SW480 (human) xenograft by Immunohistochemical analysis
数据表及文件
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SDS download
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Datasheet download
文献 (12)
ab97460 被引用在 12 文献中.
- Deng P et al. RAD21 amplification epigenetically suppresses interferon signaling to promote immune evasion in ovarian cancer. J Clin Invest 132:N/A (2022). PubMed: 36201246
- Kim JY et al. High YAP and TEAD4 immunolabelings are associated with poor prognosis in patients with gallbladder cancer. APMIS 129:729-742 (2021). PubMed: 34779030
- Drexler R et al. The clinical relevance of the Hippo pathway in pancreatic ductal adenocarcinoma. J Cancer Res Clin Oncol 147:373-391 (2021). PubMed: 33098447
- Mahadevaiah SK et al. A single-cell transcriptome atlas of marsupial embryogenesis and X inactivation. Nature 586:612-617 (2020). PubMed: 32814901
- Hwang JH et al. TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression. Nat Commun 10:421 (2019). PubMed: 30679431