JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB138246

Anti-TEAD3抗体

Anti-TEAD3 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal TEAD3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TEAD3.

查看别名

TEAD5, TEF5, TEAD3, Transcriptional enhancer factor TEF-5, DTEF-1, TEA domain family member 3, TEAD-3

1 Images
Western blot - Anti-TEAD3 antibody (AB138246)
  • WB

Unknown

Western blot - Anti-TEAD3 antibody (AB138246)

All lanes:

Western blot - Anti-TEAD3 antibody (ab138246) at 1/500 dilution

All lanes:

HUVEC cell lysate at 30 µg

Predicted band size: 49 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB

applications

免疫原

Synthetic Peptide within Human TEAD3. The exact immunogen used to generate this antibody is proprietary information.

Q99594

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500.00000 - 1/1000.00000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TEAD3 also known as TEF-5 is a transcription factor that plays an important role in regulating gene expression. It belongs to the TEA/ATTS domain family and has a molecular mass of around 47 kDa. This protein is expressed in several tissues including the heart liver and skeletal muscle suggesting its involvement in various cellular functions across different organ systems. The mechanical action of TEAD3 involves binding to DNA sequences within the nucleus to modulate transcription of target genes.
Biological function summary

TEA/ATTS domain family members like TEAD3 activate transcription of genes involved in proliferation and differentiation. TEAD3 partners with co-factors such as YAP (Yes-associated protein) to form a complex that influences gene expression patterns critical for cellular growth and development. The interactions between TEAD3 and its co-factors play a significant role in mediating pathways that sustain normal tissue function and adaptation.

Pathways

Numerous cellular functions hinge on the YAP-TEAD3 interaction a focal point of the Hippo signaling pathway which governs cell growth apoptosis and the stem cell population. In addition TEAD3 features in the Wnt signaling pathway thereby affecting processes of embryogenesis and tissue regeneration. Through these pathways TEAD3 connects with other proteins like TAZ (transcriptional coactivator with PDZ-binding motif) and β-catenin to mediate signal transduction and cellular response.

TEAD3's deregulation links to various cancers and fibrotic diseases. Aberrant activity in the Hippo pathway involving TEAD3 and YAP has been observed in hepatocellular carcinoma contributing to unchecked cellular proliferation and survival. Similarly in renal fibrosis altered TEAD3 activity impacts the expression of fibrotic markers often observed with changes in the TGF-β (transforming growth factor-beta) signaling pathway. Understanding these relationships can offer insights into developing therapeutic strategies targeting TEAD3 interactions in disease contexts.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
See full target information TEAD3
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 9:680344 PubMed34621736

2021

Down-Regulation of CXXC5 De-Represses MYCL1 to Promote Hepatic Stellate Cell Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyan Wu,Wenhui Dong,Ming Kong,Haozhen Ren,Jinglin Wang,Longcheng Shang,Zhengyi Zhu,Wei Zhu,Xiaolei Shi
View all publications
style
left-column
style
left-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。
style
left-column
style
right-column

关联产品

Select an associated product type
Alternative Product
Primary Antibodies

AB237766

Anti-TEAD3 antibody

primary-antibodies

tead3-antibody-ab237766

0

(0 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com