AB54374

Anti-TEA domain family member 2/ETF抗体[404C5a]

Name: TEA domain family member 2/ETF抗体[404C5a] (ab54374)| Abcam中文官网
Brand: Abcam Limited
SKU: AB54374
Price: 4744 CNY
Availability: InStock
Rating: 4 (1 reviews)

Anti-TEA domain family member 2/ETF antibody [404C5a]

(1 Review)

(1 Publication)

Mouse Monoclonal TEA domain family member 2/ETF antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TEAD2.

查看别名

TEF4, TEAD2, Transcriptional enhancer factor TEF-4, TEA domain family member 2, TEAD-2

1 Images

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Western blot - Anti-TEA domain family member 2/ETF antibody [404C5a] (AB54374)

The molecular weight of the band on the Western blot does not correspond to the molecular weight of the natural protein as the immunizing recombinant protein fragment was used as the test antigen.

All lanes:

Western blot - Anti-TEA domain family member 2/ETF antibody [404C5a] (ab54374)

All lanes:

immunizing recombinant protein

Predicted band size: 49 kDa

Observed band size: 36 kDa

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关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

404C5a

亚型

IgG1

不含载体蛋白

应用

applications

免疫原

Recombinant Fragment Protein within Human TEAD2. The exact immunogen used to generate this antibody is proprietary information.

Q15562

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein G

纯化说明

ab54374 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane.

存储溶液

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TEA domain family member 2 (also known as ETF or TEAD2) is a transcription factor belonging to the TEAD protein family with a molecular mass around 47 kDa. TEAD2 plays an important mechanical role in regulating gene expression by binding to enhancer regions within the DNA. You will find TEAD2 predominantly expressed in tissues such as the brain heart and skeletal muscle. This expression pattern indicates its involvement in critical cellular activities.

Biological function summary

TEAD2 functions as a participant in the transcriptional activation of target genes by forming complexes with other cofactors such as YAP and TAZ. This complex formation facilitates the modulation of cell proliferation differentiation and apoptosis. TEAD2 activation leads to transcriptional regulation of genes promoting these cellular processes signifying its importance in maintaining tissue homeostasis and development.

Pathways

TEAD2 participates importantly in the Hippo signaling pathway which plays a role in organ size determination and tumor suppression. The TEAD2 pathway interaction occurs via its association with YAP and TAZ proteins which transmit signals from cell surface receptors to the nucleus. Additionally involvement in Wnt signaling connects TEAD2 to a network of proteins regulating embryonic development and adult tissue homeostasis further highlighting its pathway integration.

Dysregulation of TEAD2 activity has implications in oncological processes especially concerning tumor growth and metastasis. TEAD2's association with YAP and TAZ is significant in cancer biology due to their role in constitutive pathway activation which can lead to uncontrolled cell growth. Abnormal TEAD2 signaling may also influence diseases linked to developmental malformations because of its regulatory activity in important developmental pathways.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

See full target information TEAD2

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Oncotarget 7:49042-49064 PubMed27119498

2016

Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype.

Applications

Unspecified application

Species

Unspecified reactive species

Ravi K Deevi,Jane McClements,Karen D McCloskey,Aliya Fatehullah,Dorota Tkocz,Arman Javadi,Robyn Higginson,Victoria Marsh Durban,Marnix Jansen,Alan Clarke,Maurice B Loughrey,Frederick C Campbell

View all publications

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Anti-TEA domain family member 2/ETF抗体[404C5a]

Anti-TEA domain family member 2/ETF antibody [404C5a]

Western blot - Anti-TEA domain family member 2/ETF antibody [404C5a] (AB54374)