AB24550

Anti-TBLR1/TBL1XR1抗体

Name: TBLR1/TBL1XR1抗体 (ab24550)| Abcam中文官网
Brand: Abcam Limited
SKU: AB24550
Price: 5107 CNY
Availability: InStock
Rating: 4 (2 reviews)

Anti-TBLR1/TBL1XR1 antibody

(2 Reviews)

(13 Publications)

Rabbit Polyclonal TBLR1/TBL1XR1 antibody. Suitable for WB and reacts with Human samples. Cited in 13 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TBL1XR1.

查看别名

IRA1, TBLR1, TBL1XR1, F-box-like/WD repeat-containing protein TBL1XR1, Nuclear receptor corepressor/HDAC3 complex subunit TBLR1, TBL1-related protein 1, Transducin beta-like 1X-related protein 1

1 Images

Unknown

Western blot - Anti-TBLR1/TBL1XR1 antibody (AB24550)

All lanes:

Western blot - Anti-TBLR1/TBL1XR1 antibody (ab24550) at 1/2000 dilution

All lanes:

HeLa nuclear extract

Predicted band size: 56 kDa

Observed band size: 60 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Recombinant Full Length Protein corresponding to Human TBL1XR1.

Q9BZK7

特异性

Does not cross-react with TBL1.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯度

Whole antiserum

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TBLR1 also known as TBL1XR1 is a protein that plays an important role in transcription regulation mechanisms. This protein with a molecular mass of approximately 64 kDa is expressed in various tissues including the brain and lungs. It functions as an adaptor protein facilitating interactions between different transcription factors and the corepressor complex. By doing so it enables the repression or activation of specific genes according to cellular needs.

Biological function summary

TBLR1 participates in the regulation of gene expression by being part of the SMRT/N-CoR repressor complex. This complex interacts with nuclear receptors to modulate gene transcription. Through this function TBLR1 contributes to processes involved in maintaining cellular homeostasis. Its role in this complex marks it as a contributor to the fine-tuning of cellular responses to external stimuli which is essential for normal cellular function.

Pathways

The regulation of transcription by TBLR1 integrates into significant signaling pathways like Wnt and nuclear receptor pathways. It partners with proteins such as beta-catenin in the Wnt signaling pathway and corepressors in the nuclear receptor pathway. Through these partnerships TBLR1 affects important developmental and metabolic processes linking transcriptional machinery to broader regulatory networks in the cell.

TBLR1 has associations with conditions such as cancer and autism spectrum disorder. Mutations or dysregulation in the TBLR1 gene can affect normal cellular signaling leading to aberrant cell growth in cancers or disrupted neural development in autism. Additionally it is connected to the action of the protein N-CoR which is also implicated in these diseases. Through these associations TBLR1 becomes a target of interest for understanding and potentially treating these disorders.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.

See full target information TBL1XR1

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文献 (13)

Recent publications for all applications. Explore the full list and refine your search

Immunity, inflammation and disease 11:e905 PubMed37382271

2023

Circ_0035292 knockdown alleviates lipopolysaccharide (LPS)-induced WI-38 cell apoptosis and inflammatory injury.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Guo,Zhouzhen Li,Chen Cheng

PloS one 17:e0268149 PubMed36413568

2022

Monoallelic variants resulting in substitutions of MAB21L1 Arg51 Cause Aniridia and microphthalmia.

Applications

Unspecified application

Species

Unspecified reactive species

Hildegard Nikki Hall,Hemant Bengani,Robert B Hufnagel,Giuseppe Damante,Morad Ansari,Joseph A Marsh,Graeme R Grimes,Alex von Kriegsheim,David Moore,Lisa McKie,Jamalia Rahmat,Catia Mio,Moira Blyth,Wee Teik Keng,Lily Islam,Meriel McEntargart,Marcel M Mannens,Veronica Van Heyningen,Joe Rainger,Brian P Brooks,David R FitzPatrick

iScience 25:104952 PubMed36065190

2022

GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Yang,Xiaocen Liu,Xiaolong Zhu,Mengying Zhang,Yingying Wang,Mingzhe Ma,Kun Lv

Molecular biology and evolution 37:3453-3468 PubMed32658962

2020

Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents.

Applications

Unspecified application

Species

Unspecified reactive species

Charlotte Moretti,Mélina Blanco,Côme Ialy-Radio,Maria-Elisabetta Serrentino,Clara Gobé,Robin Friedman,Christophe Battail,Marjorie Leduc,Monika A Ward,Daniel Vaiman,Frederic Tores,Julie Cocquet

Cancer biotherapy & radiopharmaceuticals 35:741-752 PubMed32407172

2020

Long Noncoding RNA Plasmacytoma Variant Translocation 1 Regulates Cisplatin Resistance via miR-3619-5p/TBL1XR1 Axis in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Wu,Yu Hu,Yongjie Ning,Aili Zhao,Guangwei Zhang,Lin Yan

Experimental and therapeutic medicine 17:91-98 PubMed30651768

2019

TBL1XR1 as a potential therapeutic target that promotes epithelial-mesenchymal transition in lung squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yuehua Zhao,Hao Lin,Jingwei Jiang,Mengxi Ge,Xiaohua Liang

Cell death and differentiation 24:1029-1044 PubMed28475176

2017

SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation.

Applications

WB, IP

Species

Mouse, Mouse

Charlotte Moretti,Maria-Elisabetta Serrentino,Côme Ialy-Radio,Marion Delessard,Tatiana A Soboleva,Frederic Tores,Marjorie Leduc,Patrick Nitschké,Joel R Drevet,David J Tremethick,Daniel Vaiman,Ayhan Kocer,Julie Cocquet

Oncotarget 7:39556-39571 PubMed27127173

2016

Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation.

Applications

Species

Unspecified reactive species

Garrett Daniels,Xinmin Zhang,Xuelin Zhong,Larion Santiago,Ling Hang Wang,Xinyu Wu,Jack Y Zhang,Fengxia Liang,Xin Li,Thomas A Neubert,Laurey Steinke,Ying Shen,Ross Basch,Robert Schneider,David E Levy,Peng Lee

The Journal of cell biology 204:265-79 PubMed24446484

2014

A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion.

Applications

ICC/IF, WB

Species

Drosophila melanogaster, Drosophila melanogaster

Christopher P Toret,Michael V D'Ambrosio,Ronald D Vale,Michael A Simon,W James Nelson

Genome research 22:1813-31 PubMed22955991

2012

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia.

Applications

Species

Unspecified reactive species

Stephen G Landt,Georgi K Marinov,Anshul Kundaje,Pouya Kheradpour,Florencia Pauli,Serafim Batzoglou,Bradley E Bernstein,Peter Bickel,James B Brown,Philip Cayting,Yiwen Chen,Gilberto DeSalvo,Charles Epstein,Katherine I Fisher-Aylor,Ghia Euskirchen,Mark Gerstein,Jason Gertz,Alexander J Hartemink,Michael M Hoffman,Vishwanath R Iyer,Youngsook L Jung,Subhradip Karmakar,Manolis Kellis,Peter V Kharchenko,Qunhua Li,Tao Liu,X Shirley Liu,Lijia Ma,Aleksandar Milosavljevic,Richard M Myers,Peter J Park,Michael J Pazin,Marc D Perry,Debasish Raha,Timothy E Reddy,Joel Rozowsky,Noam Shoresh,Arend Sidow,Matthew Slattery,John A Stamatoyannopoulos,Michael Y Tolstorukov,Kevin P White,Simon Xi,Peggy J Farnham,Jason D Lieb,Barbara J Wold,Michael Snyder

View all publications

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Anti-TBLR1/TBL1XR1抗体

Anti-TBLR1/TBL1XR1 antibody

Western blot - Anti-TBLR1/TBL1XR1 antibody (AB24550)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性