AB200578

Anti-TBC1D9B抗体- C-terminal

Name: TBC1D9B抗体- C-terminal (ab200578)| Abcam中文官网
Brand: Abcam Limited
SKU: AB200578
Price: 4606 CNY
Availability: InStock

Anti-TBC1D9B antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal TBC1D9B antibody. C-terminal. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TBC1D9B aa 1200 to C-terminus.

查看别名

KIAA0676, TBC1D9B, TBC1 domain family member 9B

2 Images

Supplier Data

Immunoprecipitation - Anti-TBC1D9B antibody - C-terminal (AB200578)

Immunoprecipitation analysis of 293T cell lysate (in NETN buffer, 0.5 or 1.0 mg per IP reaction; 20% of IP loaded) labeling TBC1D9B using ab200578 at 6 μg per reaction (lane 1). A Control IgG was used in lane 2. For blotting immunoprecipitated TBC1D9B, ab200578 was used at 1 μg/ml.

All lanes:

Immunoprecipitation - Anti-TBC1D9B antibody - C-terminal (ab200578)

Predicted band size: 141 kDa

true

Exposure time: 30s

Supplier Data

Western blot - Anti-TBC1D9B antibody - C-terminal (AB200578)

Lysates prepared using NETN lysis buffer.

All lanes:

Western blot - Anti-TBC1D9B antibody - C-terminal (ab200578) at 0.1 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

293T whole cell lysate at 50 µg

Lane 3:

Jurkat whole cell lysate at 50 µg

Predicted band size: 141 kDa

true

Exposure time: 3min

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IP, WB

applications

免疫原

Synthetic Peptide within Human TBC1D9B aa 1200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q66K14

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TBC1D9B also known as TBC domain family member 9B is a protein characterized by its role as a GTPase-activating protein for Rab family proteins. It has a molecular mass of approximately 145 kDa. TBC1D9B is expressed widely in human tissues including but not limited to the heart brain and skeletal muscle. This protein interacts with small GTPases regulating their cycle of activation and inactivation which is important for intracellular trafficking processes.

Biological function summary

TBC1D9B participates in the regulation of endosomal dynamics and autophagy. This protein is part of the broader Rab GTPase network influencing vesicular transport and membrane fusion events within the cell. In various tissues TBC1D9B modulates cellular functions such as receptor recycling and protein degradation thereby maintaining cellular homeostasis. The protein's role in endosomal transport is particularly important in neurons where it impacts synaptic vesicle cycling.

Pathways

Several intracellular trafficking pathways engage TBC1D9B. It plays a significant role in the insulin signaling pathway and the endocytic pathway. By interacting with pathways such as these TBC1D9B influences the proper functioning of Rab GTPases notably Rab11. This association is vital for controlling endosomal sorting and recycling processes that are instrumental in various cellular activities like nutrient uptake and signaling cascades linked with cell growth and metabolism.

Certain pathologies demonstrate a connection with TBC1D9B. Alterations in its function have been implicated in diabetes due to the protein's influence on insulin action and glucose regulation. Additionally abnormal activity of TBC1D9B links to neurodegenerative conditions given its critical role in neural trafficking processes. The relationship between TBC1D9B and Rab GTPases like Rab11 underlines its importance in the pathophysiology of these disorders influencing disease progression through impaired vesicular transport.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

May act as a GTPase-activating protein for Rab family protein(s).

See full target information TBC1D9B

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2416590 PubMed40298908

2025

Nuclear-Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Haiying Liu,Jiaqian Feng,Tingting Pan,Pinggen Zhang,Ling Ye,Zetan Jiang,Zilong Zhou,Qiankun Mao,Jian Li,Xinyi Yang,Ping Gao,De Huang,Huafeng Zhang

View all publications

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Abcam Product Promise

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Anti-TBC1D9B抗体- C-terminal

Anti-TBC1D9B antibody - C-terminal

Immunoprecipitation - Anti-TBC1D9B antibody - C-terminal (AB200578)

Western blot - Anti-TBC1D9B antibody - C-terminal (AB200578)