AB200692

Anti-TBC1D2抗体

Name: TBC1D2抗体 (ab200692)| Abcam中文官网
Brand: Abcam Limited
SKU: AB200692
Price: 4560 CNY
Availability: InStock

Anti-TBC1D2 antibody

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(1 Publication)

Rabbit Polyclonal TBC1D2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TBC1D2 aa 400-500.

查看别名

PARIS1, PP8997, TBC1D2A, TBC1D2, TBC1 domain family member 2A, Armus, Prostate antigen recognized and identified by SEREX 1, PARIS-1

1 Images

Supplier Data

Western blot - Anti-TBC1D2 antibody (AB200692)

All lanes:

Western blot - Anti-TBC1D2 antibody (ab200692)

Lane 1:

MCF7 whole cell lysate

Lane 2:

sp2/0 whole cell lysate

Lane 3:

PC12 whole cell lysate

Predicted band size: 105 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Rat, Human

应用

applications

免疫原

Synthetic Peptide within Human TBC1D2 aa 400-500. The exact immunogen used to generate this antibody is proprietary information.

Q9BYX2

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab200692 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

存储溶液

pH: 7.2 Preservative: 0.097% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TBC1D2 also known as Armus is a protein involved in tethering and trafficking of endosomes exhibiting a molecular mass of approximately 120 kDa. It interacts with Rab7 a small GTPase to regulate the elongation of endosomal structures. Expression of TBC1D2 is found in many tissues with significant levels in the brain and adipose tissue. The protein functions as a GAP (GTPase-activating protein) facilitating the conversion of Rab7-GTP to Rab7-GDP which is an important process in endosomal transport and maturation.

Biological function summary

TBC1D2 plays a role in the regulation of cellular autophagy and endocytosis. It is part of the endosomal complex involved in cargo sorting and trafficking affecting the lysosomal degradation pathway. The interaction with Rab7 suggests its involvement in the fusion of late endosomes with lysosomes. Additionally TBC1D2 regulates actin cytoskeleton dynamics by modulating signal transduction pathways impacting various cellular processes such as cell migration and morphogenesis.

Pathways

TBC1D2 participates in the endocytic and autophagic pathways influencing cellular homeostasis and response to stress. In the endocytic pathway it works closely with proteins like Rab7 to modulate endosome maturation. TBC1D2 also intersects with other autophagic-related proteins impacting cellular recycling processes important for maintaining cellular environment stability and responding to nutrient availability.

TBC1D2 is linked to neurodegenerative and metabolic conditions. Aberrant regulation of its activity is associated with Alzheimer's disease affecting amyloid precursor protein processing and clearance. Moreover TBC1D2's involvement in adipose tissue function connects it to obesity-related disorders influencing body weight and metabolism. Its interactions with proteins like Rab7 in these disease contexts underline its critical role in cellular trafficking and metabolic regulation.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.

See full target information TBC1D2

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

RNA biology 17:784-793 PubMed32174258

2020

LncRNA MAGI2-AS3 inhibits the self-renewal of leukaemic stem cells by promoting TET2-dependent DNA demethylation of the LRIG1 promoter in acute myeloid leukaemia.

Applications

Unspecified application

Species

Unspecified reactive species

Lijuan Chen,Xu Fan,Jianhua Zhu,Xuexin Chen,Yiling Liu,Hao Zhou

View all publications

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Anti-TBC1D2抗体

Anti-TBC1D2 antibody

Western blot - Anti-TBC1D2 antibody (AB200692)