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AB131354

Anti-Tau (phospho S262) 抗体

Anti-Tau (phospho S262) antibody

3

(2 Reviews)

|

(29 Publications)

Rabbit Polyclonal TAU phospho S262 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 29 publications.

查看别名

MAPTL, MTBT1, TAU, MAPT, Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-Tau (phospho S262) antibody (AB131354)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Tau (phospho S262) antibody (AB131354)

Immunofluorescence of methanol-fixed HeLa cells (ab29545) staining Tau (phospho S262) with ab131354 antibody at a dilution of 1/100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau (phospho S262) antibody (AB131354)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau (phospho S262) antibody (AB131354)

Immunohistochemical analysis of paraffin embedded Rat hippocampal region tissue from a model with Alzheimer's disease labelling Tau (phospho S262) with ab131354 antibody at a dilution of 1/50.

Western blot - Anti-Tau (phospho S262) antibody (AB131354)
  • WB

Unknown

Western blot - Anti-Tau (phospho S262) antibody (AB131354)

All lanes:

Western blot - Anti-Tau (phospho S262) antibody (ab131354) at 1/500 dilution

Lane 1:

Mouse brain tissue extract with immunizing peptide

Lane 2:

Mouse brain tissue extract

Predicted band size: 78 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Mouse, Rat, Human

应用

ICC/IF, WB, IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特异性

The specificity of this antibody refers to P10636-8.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
纯化说明
ab131354 was purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide.
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Tau also known as microtubule-associated protein Tau (MAPT) plays an important role in stabilizing microtubules in neuronal cells. Tau is primarily found in the central nervous system but also exists in peripheral neurons. Human Tau protein comes in six isoforms due to alternative splicing with molecular weights ranging from 48 kDa to 67 kDa. This protein predominantly locates in the axons of neurons where it maintains the stability of microtubule tracks necessary for axonal transport.
Biological function summary

Tau is involved in the assembly and stabilization of microtubules essential for maintaining neuronal structure. It interacts with microtubule-binding domains (MBD) to bind and bundle microtubules facilitating intracellular transport. Tau forms a part of the neuronal cytoskeleton complex working closely with other cytoskeletal proteins to preserve the proper axonal transport and function. Abnormally phosphorylated Tau often termed phospho-Tau disrupts this complex affecting microtubule stability.

Pathways

Tau has critical involvement in several signaling cascades such as the microtubule-binding and transport pathways. Glycogen synthase kinase 3 beta (GSK3β) and cyclin-dependent kinase 5 (CDK5) frequently phosphorylate Tau controlling its interaction with microtubules. Phosphorylated Tau accumulates leading to the formation of neurofibrillary tangles often observed in neurodegenerative conditions. Additionally Tau interacts with GAPDH impacting cellular energy regulation through potential pathway cross-talk involving oxidative stress responses.

Tau is closely associated with Alzheimer's disease and frontotemporal dementia. In Alzheimer's disease hyperphosphorylated Tau aggregates into paired helical filaments forming neurofibrillary tangles while similar aggregates are observed in frontotemporal dementia. In these conditions Tau links to amyloid precursor protein (APP) where misregulated phosphorylation-driven interactions contribute to neurodegeneration. Identifying phospho-Tau and its altered interactions with related proteins aids in understanding and potentially treating these disorders.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

The protein expressed by the MAPT gene promotes microtubule assembly and stability and might be involved in establishing and maintaining neuronal polarity. Its C-terminus binds axonal microtubules, and the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between the two. Axonal polarity is predetermined by MAPT localization within the neuronal cell's domain defined by the centrosome. The short isoforms allow cytoskeleton plasticity, whereas the longer isoforms may preferentially play a role in its stabilization. This supplementary information is collated from multiple sources and compiled automatically.
See full target information MAPT phospho S262
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文献 (29)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 16:1616775 PubMed40969938

2025

Long-term gabapentin treatment impairs cognitive function in aged mice via tau hyperphosphorylation.

Applications

Unspecified application

Species

Unspecified reactive species

Suyun Xia,Zerong You,Xinbo Wu,Jinsheng Yang,Shiyu Wang,Na Li,Jiajia Dai,Yuanlin Dong,Lucy Chen,Min Yan,Shiqian Shen,Zhongcong Xie,Jianren Mao

International journal of molecular sciences 26: PubMed40332373

2025

Acanthopanax Senticosus Saponins Prevent Cognitive Decline in Rats with Alzheimer's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Xue-Min Cui,Wang Wang,Lin Yang,Bao-Wen Nie,Qian Liu,Xiao-Hui Li,Dong-Xiao Duan

Biomedicines 12: PubMed39595152

2024

Brain Injury and Neurodegeneration: Molecular, Functional, and Translational Approach 2.0.

Applications

Unspecified application

Species

Unspecified reactive species

Pankaj Ahluwalia,Pankaj Gaur,Meenakshi Ahluwalia,Kumar Vaibhav

PloS one 19:e0313507 PubMed39536002

2024

Palmitoyl-L-carnitine induces tau phosphorylation and mitochondrial dysfunction in neuronal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Gwangho Yoon,Min Kyoung Kam,Young Ho Koh,Chulman Jo

Acta neuropathologica communications 12:94 PubMed38867338

2024

Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold.

Applications

Unspecified application

Species

Unspecified reactive species

Ujjayini Ghosh,Eric Tse,Hyunjun Yang,Marie Shi,Christoffer D Caro,Feng Wang,Gregory E Merz,Stanley B Prusiner,Daniel R Southworth,Carlo Condello

Brain communications 6:fcae136 PubMed38712317

2024

ablation attenuates pathological phenotypes in a mouse model of tauopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Grigorii Sultanakhmetov,Sophia Jobien M Limlingan,Aoi Fukuchi,Keisuke Tsuda,Hirokazu Suzuki,Iori Kato,Taro Saito,Adam Z Weitemier,Kanae Ando

British journal of anaesthesia 131:726-738 PubMed37537117

2023

Sevoflurane anaesthesia induces cognitive impairment in young mice through sequential tau phosphorylation.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Liang,Mengzhu Li,Miao Xu,Yiying Zhang,Yuanlin Dong,Sulpicio G Soriano,Mary Ellen McCann,Guang Yang,Zhongcong Xie

Neural regeneration research 18:1795-1801 PubMed36751808

2023

Death-associated protein kinase 1 is associated with cognitive dysfunction in major depressive disorder.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Hui Li,Hong-Can Zhu,Xue-Min Cui,Wang Wang,Lin Yang,Li-Bo Wang,Neng-Wei Hu,Dong-Xiao Duan

Cell reports 42:111912 PubMed36640304

2023

Axonal plasticity in response to active forces generated through magnetic nano-pulling.

Applications

Unspecified application

Species

Unspecified reactive species

Alessandro Falconieri,Sara De Vincentiis,Valentina Cappello,Domenica Convertino,Ravi Das,Samuele Ghignoli,Sofia Figoli,Stefano Luin,Frederic Català-Castro,Laura Marchetti,Ugo Borello,Michael Krieg,Vittoria Raffa

Molecular neurobiology 59:5856-5873 PubMed35804281

2022

DHCR24 Knockdown Induces Tau Hyperphosphorylation at Thr181, Ser199, Ser262, and Ser396 Sites via Activation of the Lipid Raft-Dependent Ras/MEK/ERK Signaling Pathway in C8D1A Astrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Meiting Mai,Xiaorou Guo,Yue Huang,Wenbin Zhang,Yixuan Xu,Ying Zhang,Xiaojing Bai,Junfeng Wu,Hengbing Zu
View all publications
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