AB195044

重组Anti-TARC/CCL17抗体[EPR15861]

Name: TARC/CCL17抗体[EPR15861] (ab195044)| Abcam中文官网
Brand: Abcam Limited
SKU: AB195044
Price: 2640 CNY
Availability: InStock
Rating: 4 (1 reviews)

Anti-TARC/CCL17 antibody [EPR15861]

RabMAb
Recombinant
了解详情

(1 Review)

(4 Publications)

Anti-TARC/CCL17 antibody [EPR15861] (ab195044) is a rabbit monoclonal antibody detecting TARC/CCL17 in IHC-P. Suitable for Human.

- Biophysical QC for unrivalled batch-batch consistency

查看别名

SCYA17, TARC, CCL17, C-C motif chemokine 17, CC chemokine TARC, Small-inducible cytokine A17, Thymus and activation-regulated chemokine

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TARC/CCL17 antibody [EPR15861] (AB195044)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TARC/CCL17 antibody [EPR15861] (AB195044)

Immunohistochemical analysis of paraffin-embedded Human Hodgkin lymphoma tissue labeling TARC/CCL17 with ab195044 at 1/500 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) (ab97051) secondary antibody at 1/500 and counter-stained with Hematoxylin.
Inset : Negative control.

Note : Cytoplasm staining on humanHodgkin's lymphoma tissue was observed.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TARC/CCL17 antibody [EPR15861] (AB195044)

Immunohistochemical analysis of paraffin-embedded Human non-Hodgkin lymphoma tissue labeling TARC/CCL17 with ab195044 at 1/500 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) (ab97051) secondary antibody at 1/500 and counter-stained with Hematoxylin.
Inset : Negative control.

Note : Cytoplasm staining on human non-Hodgkin lymphoma tissue was observed.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TARC/CCL17 antibody [EPR15861] (AB195044)

Immunohistochemical analysis of paraffin-embedded Human tonsil tissue labeling TARC/CCL17 with ab195044 at 1/500 dilution, followed byGoat Anti-Rabbit IgG H&L (HRP) (ab97051) secondary antibody at 1/500 and counter-stained with Hematoxylin.
Inset : Negative control.

Note : Cytoplasm staining on human tonsil tissue was observed.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

不同偶联物与剂型 (1)

Carrier free

Anti-TARC/CCL17 antibody [EPR15861] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR15861

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.", "ICC-species-checked": "notRecommended", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>" } } }

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产品详情

What is this antibody validated in?
Anti-TARC/CCL17 antibody [EPR15861] (ab195044) is a rabbit recombinant monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human samples.

Other related products
We have a range of other formats of antibody clone [EPR15861] also available for your convenience: ab195044, Carrier free - ab232659

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Conditional Ambient

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TARC also known as CCL17 is a chemokine with a molecular mass of approximately 8 kDa. It is mainly expressed in the thymus but also found in the lung liver and lymph nodes. CCL17 plays an important role in immune response by signaling through the CCR4 receptor. It functions as a ligand that guides the movement of T-helper 2 (Th2) cells regulatory T cells (Tregs) and other immune cells to sites of inflammation.

Biological function summary

CCL17 acts as a chemotactic agent attracting specific immune cells especially T lymphocytes to inflammatory regions. This protein does not operate as part of a larger protein complex but engages directly by binding to receptors on the target immune cells. Localized expression of CCL17 increases in conditions where enhanced Th2 cell response is needed such as allergic or autoimmune responses.

Pathways

CCL17 plays a significant role in the cell signaling pathway called the chemokine signaling pathway. Through this pathway CCL17 interacts with the CCR4 receptor which helps mediate immune cell migration and adhesion. This interaction is critical for establishing the adaptive immune response. CCL17 and CCR4 support the trafficking of Th2 cells during immune reactions and pathogen defense.

CCL17 associates with asthma and atopic dermatitis where Th2 cell recruitment and activity are heightened. In asthma increased CCL17 levels exacerbate inflammatory response in the airways. In atopic dermatitis CCL17 presence corresponds with the intensity of the skin inflammation. These conditions are linked to the overactivity of Th2 cytokines such as IL-4 (H4L3) which collaborate with CCL17 to drive allergic responses.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes (PubMed : 8702936, PubMed : 9169480). Acts by binding to CCR4 at T-cell surface (PubMed : 10540332, PubMed : 9169480). Mediates GM-CSF/CSF2-driven pain and inflammation (PubMed : 27525438). In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation (By similarity). Plays a role in wound healing, mainly by inducing fibroblast migration into the wound (By similarity).

See full target information CCL17

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:31580 PubMed39738081

2024

The expression of CCL17 and potential prognostic value on tumor immunity in thyroid carcinoma based on bioinformatics analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Xue Gu,Bingfeng Chen,Shengcan Zhang,Xinyu Zhai,Ying Hu,Hui Ye

Journal for immunotherapy of cancer 12: PubMed38816233

2024

Interactions between LAMP3+ dendritic cells and T-cell subpopulations promote immune evasion in papillary thyroid carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiyuan Wang,Xiaoyu Ji,Ye Zhang,Fan Yang,Hongyue Su,Hao Zhang,Zhendong Li,Wenqian Zhang,Wei Sun

Liver international : official journal of the International Association for the Study of the Liver 40:1327-1338 PubMed32187823

2020

HBV promotes the recruitment of IL-17 secreting T cells via chemokines CCL22 and CCL17.

Applications

Unspecified application

Species

Unspecified reactive species

Ka Zhang,Yanqiong Liu,Xiaoan Yang,Haixia Sun,Xin Shu,Yeqiong Zhang,Hong Cao,Mengdi Wu,Nan Liu,Yong Zou,Qihuan Xu,Gang Li

The Journal of clinical investigation 128:5235-5250 PubMed30204129

2018

HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk.

Applications

Unspecified application

Species

Unspecified reactive species

Yingying Wang,Xiaoling Weng,Luoyang Wang,Mingang Hao,Yue Li,Lidan Hou,Yu Liang,Tianqi Wu,Mengfei Yao,Guowen Lin,Yiwei Jiang,Guohui Fu,Zhaoyuan Hou,Xiangjun Meng,Jinsong Lu,Jianhua Wang

View all publications

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重组Anti-TARC/CCL17抗体[EPR15861]