Anti-TANK/TRAF2抗体(ab47632)
Key features and details
- Rabbit polyclonal to TANK/TRAF2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-TANK/TRAF2抗体 -
描述
兔多克隆抗体to TANK/TRAF2 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human TANK/TRAF2.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab47632于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 47 kDa).
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| 说明 |
|---|
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WB
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 47 kDa). |
靶标
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功能
Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity. -
组织特异性
Ubiquitous. -
序列相似性
Contains 1 C2H2-type zinc finger. -
翻译后修饰
Phosphorylated by IKBKE. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 10010 Human
- Omim: 603893 Human
- SwissProt: Q92844 Human
- Unigene: 132257 Human
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别名
- I TRAF antibody
- I-TRAF antibody
- ITRAF antibody
see all
图片
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Western blot - Anti-TANK/TRAF2 antibody (ab47632)
Western Blot of human kidney lysate labeling TANK/TRAF2 with Anti-TANK/TRAF2 antibody (ab47632) at (1) 1 and (2) 2μg/ml.
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Western blot - Anti-TANK/TRAF2 antibody (ab47632)Lane 1 : Anti-TANK/TRAF2 antibody (ab47632) at 0.5 µg/ml
Lane 2 : Anti-TANK/TRAF2 antibody (ab47632) at 1 µg/ml
Lane 3 : Anti-TANK/TRAF2 antibody (ab47632) at 2 µg/ml
All lanes : Daudi Cell Lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 47 kDa
Observed band size: 55 kDa why is the actual band size different from the predicted?
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab47632 被引用在 1 文献中.
- Scrima N et al. Rabies virus P protein binds to TBK1 and interferes with the formation of innate immunity-related liquid condensates. Cell Rep 42:111949 (2023). PubMed: 36640307