AB105458

Anti-Talin 2抗体[68E7]

Name: Talin 2抗体[68E7] (ab105458)| Abcam中文官网
Brand: Abcam Limited
SKU: AB105458
Price: 4606 CNY
Availability: InStock
Rating: 5 (1 reviews)

Anti-Talin 2 antibody [68E7]

(1 Review)

(12 Publications)

Mouse Monoclonal Talin 2 antibody. Suitable for IP, ELISA, WB, ICC/IF, IHC-Fr and reacts with Mouse samples. Cited in 12 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Tln2 aa 450-950.

查看别名

Talin-2, Tln2

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

68E7

亚型

IgG2b

不含载体蛋白

反应种属

Mouse

应用

IHC-Fr, ICC/IF, ELISA, IP, WB

applications

免疫原

Recombinant Fragment Protein within Mouse Tln2 aa 450-950. The exact immunogen used to generate this antibody is proprietary information.

Q71LX4

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }

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产品详情

Growth Conditions: RPMI1650 + Glu + Pen + Strep + 10% FCS @ 37°C + 5%CO2

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Talin 2 also known as TLN2 is a large cytoskeletal protein approximately 270 kDa in mass. It acts mechanically as an important player in linking integrins to the actin cytoskeleton supporting the structural integrity of cells. Talin 2 is expressed in various tissues including muscle and neuronal systems with expression patterns similar to Talin 1 but has distinct roles in cellular adhesion and signal transduction.

Biological function summary

Talin 2 plays a significant role in cell adhesion and migration processes. It is part of a complex that includes integrins and other cytoskeletal proteins facilitating the transmission of mechanical signals across the cell membrane. This protein aids in focal adhesion assembly ensuring proper cellular responses to external stimuli. Talin 2 contributes to stabilizing intracellular interactions which are essential for maintaining tissue structure and cell motility.

Pathways

Talin 2 is deeply embedded in integrin-mediated signaling and the cytoskeletal organization pathway. It modulates interactions between integrins and F-actin orchestrating actin dynamics and contributing to cellular adherence junctions. Talin 2 functions closely with proteins like vinculin which supports actin filament linkage and reinforces mechanical stability under tension.

Talin 2 has been linked to muscular dystrophies and certain neuropathies. Mutations or dysregulation in Talin 2 can impair muscle function as its interaction with dystrophin is critical for muscle integrity. Additionally disruptions in Talin 2 mediated signaling could contribute to neurodegenerative disorders where its interactions with integrins can affect neuronal connectivity and survival. Understanding Talin 2's role in these conditions may provide insights for therapeutic interventions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).

See full target information Tln2

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文献 (12)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:6870 PubMed40715114

2025

Mammalian cells measure the extracellular matrix area and respond through switching the adhesion state.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaole Wang,Pengli Wang,Lihang Zhang,Tianyu Xu,Seungkuk Ahn,Upnishad Sharma,Han Yu,Nico Strohmeyer,Daniel J Müller

Communications biology 8:948 PubMed40544224

2025

Consolidation of cell-ECM adhesion through direct talin-mediated actin linkage is essential for mouse embryonic morphogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjun Deng,Rosalyn L Carr,Rhea R Kaul,Marina Pavlova-Deb,Amanda Haage,Pere Roca-Cusachs,Guy Tanentzapf

Nature communications 15:8182 PubMed39294148

2024

β2 integrins impose a mechanical checkpoint on macrophage phagocytosis.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander H Settle,Benjamin Y Winer,Miguel M de Jesus,Lauren Seeman,Zhaoquan Wang,Eric Chan,Yevgeniy Romin,Zhuoning Li,Matthew M Miele,Ronald C Hendrickson,Daan Vorselen,Justin S A Perry,Morgan Huse

Cell reports 40:111091 PubMed35858563

2022

Adherens junctions stimulate and spatially guide integrin activation and extracellular matrix deposition.

Applications

Unspecified application

Species

Unspecified reactive species

Rania Hadjisavva,Ouranio Anastasiou,Pantelis S Ioannou,Maria Zheltkova,Paris A Skourides

eLife 10: PubMed33783351

2021

Pre-complexation of talin and vinculin without tension is required for efficient nascent adhesion maturation.

Applications

Unspecified application

Species

Unspecified reactive species

Sangyoon J Han,Evgenia V Azarova,Austin J Whitewood,Alexia Bachir,Edgar Guttierrez,Alex Groisman,Alan R Horwitz,Benjamin T Goult,Kevin M Dean,Gaudenz Danuser

Nature communications 11:6403 PubMed33335089

2020

Metavinculin modulates force transduction in cell adhesion sites.

Applications

Unspecified application

Species

Unspecified reactive species

Verena Kanoldt,Carleen Kluger,Christiane Barz,Anna-Lena Schweizer,Deepak Ramanujam,Lukas Windgasse,Stefan Engelhardt,Anna Chrostek-Grashoff,Carsten Grashoff

The Journal of cell biology 216:3785-3798 PubMed28912124

2017

Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.

Applications

Unspecified application

Species

Unspecified reactive species

Ralph T Böttcher,Maik Veelders,Pascaline Rombaut,Jan Faix,Marina Theodosiou,Theresa E Stradal,Klemens Rottner,Roy Zent,Franz Herzog,Reinhard Fässler

eLife 5: PubMed27410476

2016

Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions.

Applications

Species

Unspecified reactive species

Benjamin P Bouchet,Rosemarie E Gough,York-Christoph Ammon,Dieudonnée van de Willige,Harm Post,Guillaume Jacquemet,Af Maarten Altelaar,Albert Jr Heck,Benjamin T Goult,Anna Akhmanova

BMC cancer 16:45 PubMed26822056

2016

Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell.

Applications

Unspecified application

Species

Unspecified reactive species

Kun-Peng Fang,Wei Dai,Yan-Hong Ren,Ye-Chuan Xu,She-Min Zhang,Ye-Ben Qian

eLife 5:e10130 PubMed26821125

2016

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin.

Applications

Species

Mouse

Marina Theodosiou,Moritz Widmaier,Ralph T Böttcher,Emanuel Rognoni,Maik Veelders,Mitasha Bharadwaj,Armin Lambacher,Katharina Austen,Daniel J Müller,Roy Zent,Reinhard Fässler

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Talin 2抗体[68E7]

Anti-Talin 2 antibody [68E7]

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

免疫原

反应性数据

产品详情

性能和储存信息

形式

纯化工艺

存储溶液

运输条件

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (12)

Abcam Product Promise

Anti-Talin 2抗体[68E7]

Anti-Talin 2 antibody [68E7]

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

免疫原

替代产品

Primary Antibodies

搭配使用产品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

反应性数据

产品详情

性能和储存信息

形式

纯化工艺

存储溶液

运输条件

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (12)

Abcam Product Promise