Anti-Talin 1抗体[93E12] (ab104913)
Key features and details
- Mouse monoclonal [93E12] to Talin 1
- Suitable for: ELISA, WB, ICC/IF, IHC-P, IP
- Reacts with: Human
- Isotype: IgG1
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Talin 1抗体[93E12]
参阅全部 Talin 1 一抗 -
描述
小鼠单克隆抗体[93E12] to Talin 1 -
宿主
Mouse -
特异性
ab104913 can be used for specific detection of the focal adhesion protein Talin 1 and does not cross react with Talin 2. -
经测试应用
适用于: ELISA, WB, ICC/IF, IHC-P, IPmore details -
种属反应性
与反应: Human -
免疫原
Recombinant fragment, corresponding to amino acids 780-850 of Talin 1.
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阳性对照
- Fibroblasts
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常规说明
Growth Conditions: RPMI1650 + Glu + Pen + Strep + 10% FCS @ 37C + 5%CO2.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.02% Sodium azide
Constituent: 99.98% PBS -
Concentration information loading... -
纯度
Protein A purified -
Primary antibody说明
Growth Conditions: RPMI1650 + Glu + Pen + Strep + 10% FCS @ 37C + 5%CO2. -
克隆
单克隆 -
克隆编号
93E12 -
骨髓瘤
NS0/1 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab104913于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration.
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| ICC/IF |
Use at an assay dependent concentration.
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| IHC-P |
Use at an assay dependent concentration.
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| IP |
Use at an assay dependent concentration.
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| 说明 |
|---|
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ELISA
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. |
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ICC/IF
Use at an assay dependent concentration. |
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IHC-P
Use at an assay dependent concentration. |
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IP
Use at an assay dependent concentration. |
靶标
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功能
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. -
序列相似性
Contains 1 FERM domain.
Contains 1 I/LWEQ domain. -
细胞定位
Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cell surface. Cell junction, focal adhesion. Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity). - Information by UniProt
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数据库链接
- Entrez Gene: 7094 Human
- Omim: 186745 Human
- SwissProt: Q9Y490 Human
- Unigene: 471014 Human
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别名
- ILWEQ antibody
- Talin 1 antibody
- Talin antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab104913 被引用在 5 文献中.
- Chen P et al. Talin-1 interaction network promotes hepatocellular carcinoma progression. Oncotarget 8:13003-13014 (2017). PubMed: 28099903
- van de Klundert MA et al. Hepatitis B Virus Protein X Induces Degradation of Talin-1. Viruses 8:N/A (2016). WB ; Human . PubMed: 27775586
- Kumar A et al. Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity. J Cell Biol 213:371-83 (2016). WB . PubMed: 27161398
- Liu J et al. Talin determines the nanoscale architecture of focal adhesions. Proc Natl Acad Sci U S A 112:E4864-73 (2015). PubMed: 26283369
- Sun J et al. MicroRNA-9 is a ponderable index for the prognosis of human hepatocellular carcinoma. Int J Clin Exp Med 8:17748-56 (2015). PubMed: 26770365