Anti-TACI抗体(ab5994)
Key features and details
- Rabbit polyclonal to TACI
- Suitable for: ICC, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-TACI抗体
参阅全部 TACI 一抗 -
描述
兔多克隆抗体to TACI -
宿主
Rabbit -
经测试应用
适用于: ICC, WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide within Human TACI aa 1-50 (N terminal). The exact sequence is proprietary.
(Peptide available asab6244) -
阳性对照
- WB: K562 and U937 whole cell lysates. ICC: K562 cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Stable for 12 months at -20°C. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
应用 | Ab评论 | 说明 |
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ICC |
Use a concentration of 2 µg/ml.
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WB |
Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 32 kDa.
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说明 |
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ICC
Use a concentration of 2 µg/ml. |
WB
Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 32 kDa. |
靶标
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功能
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. -
组织特异性
Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells. -
疾病相关
Defects in TNFRSF13B are the cause of immunodeficiency common variable type 2 (CVID2) [MIM:240500]. CVID2 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
Defects in TNFRSF13B are a cause of immunoglobulin A deficiency 2 (IGAD2) [MIM:609529]. Selective deficiency of immunoglobulin A (IGAD) is the most common form of primary immunodeficiency, with an incidence of approximately 1 in 600 individuals in the western world. Individuals with symptomatic IGAD often have deficiency of IgG subclasses or decreased antibody response to carbohydrate antigens such as pneumococcal polysaccharide vaccine. Individuals with IGAD also suffer from recurrent sinopulmonary and gastrointestinal infections and have an increased incidence of autoimmune disorders and of lymphoid and non-lymphoid malignancies. In vitro studies have suggested that some individuals with IGAD have impaired isotype class switching to IgA and others may have a post-switch defect. IGAD and CVID have been known to coexist in families. Some individuals initially present with IGAD1 and then develop CVID. These observations suggest that some cases of IGAD and CVID may have a common etiology. -
序列相似性
Contains 2 TNFR-Cys repeats. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 23495 Human
- Omim: 604907 Human
- SwissProt: O14836 Human
- Unigene: 158341 Human
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别名
- CD 267 antibody
- CD267 antibody
- CD267 antigen antibody
see all
图片
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Western blot analysis of TACI in K562 (A) and U937 (B) cell lysates with ab5994 at 5
µ g/ml. Western blot analysis of TACI in K562 (A) and U937 (B) cell lysates with ab5994 at 5 µg/ml. -
ab5994 staining TACI in K562 cells with TACI antibody at 2 µg/ml by ICC/IF.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab5994 尚未被引用在任何文献中。