AB217130

Anti-Syntaxin-5抗体

Name: Syntaxin-5抗体 (ab217130)| Abcam中文官网
Brand: Abcam Limited
SKU: AB217130
Price: 4845 CNY
Availability: InStock

Anti-Syntaxin-5 antibody

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(3 Publications)

Rabbit Polyclonal Syntaxin-5 antibody. Suitable for IP and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human STX5 aa 1-50.

查看别名

STX5A, STX5, Syntaxin-5

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Supplier Data

Immunoprecipitation - Anti-Syntaxin-5 antibody (AB217130)

Syntaxin-5 was immunoprecipitated from 0.5 to 1mg of HeLa whole cell lysate (prepared using NETN lysis buffer) with ab217130 or control IgG at 6 μg.

Western blot was performed on the immunoprecipitates (20% of IP loaded) using ab217130 at 1 μg/mL.

Lane 1 : ab127130 used in IP.
Lane 2 : Control IgG used in IP.

All lanes:

Immunoprecipitation - Anti-Syntaxin-5 antibody (ab217130)

Predicted band size: 40 kDa

true

Exposure time: 30s

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Synthetic Peptide within Human STX5 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q13190

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Syntaxin-5 also known as STX5 is a target protein with a molecular mass of around 35 kDa. It plays a central role in vesicle trafficking processes. Syntaxin-5 is part of the SNARE complex where it functions to mediate membrane fusion of vesicles essential for intracellular transport. The protein is expressed ubiquitously but has higher expression in brain and kidney tissues reflecting its diverse cellular functions.

Biological function summary

Syntaxin-5 is a critical component of the molecular machinery controlling vesicular transport. As a member of the Golgi apparatus Syntaxin-5 interacts within the SNARE complex to facilitate the precise delivery of cargo between endoplasmic reticulum and Golgi or Golgi to plasma membrane. Its role as a hub in intracellular transport highlights its importance in maintaining cellular homeostasis and ensuring the distribution of proteins and lipids.

Pathways

Syntaxin-5 sits prominently within intracellular trafficking routes particularly involved in the ER-Golgi transport and Golgi-to-plasma membrane pathways. It functions alongside proteins such as Bet1 and Membrin in vesicular transport processes. Together these proteins contribute to the maintenance of Golgi structure and the regulation of vesicle budding ensuring proper cellular logistics.

Syntaxin-5 has links to neurodegenerative conditions and metabolic syndromes. Notably disruptions in its function can relate to Alzheimer's disease where it affects amyloid precursor protein processing. Syntaxin-5 also interacts with proteins like Vti1a which is implicated in lysosomal storage disorders highlighting its broader relevance to diseases involving vesicle transport dysfunction.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.. Isoform 2. Required for Golgi to endoplasmic reticulum retrogade transport, and for intra-Golgi transport.. (Microbial infection) Required for the efficient production of infectious virion during human cytomegalovirus infection. Mechanistically, participates in the formation of the cytoplasmic viral assembly compartment where tegument acquisition and envelopment occur.

See full target information STX5

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Cancer immunology, immunotherapy : CII 74:37 PubMed39738657

2025

Targeting OAS3 for reversing M2d infiltration and restoring anti-tumor immunity in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Shaopeng Zhang,Ximo Xu,Kundong Zhang,Changzheng Lei,Yitian Xu,Pengshan Zhang,Yuan Zhang,Haitao Gu,Chen Huang,Zhengjun Qiu

Virulence 11:607-635 PubMed32420802

2020

TMT-based quantitative proteomics analysis reveals the attenuated replication mechanism of Newcastle disease virus caused by nuclear localization signal mutation in viral matrix protein.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiqiang Duan,Chao Yuan,Yifan Han,Lei Zhou,Jiafu Zhao,Yong Ruan,Jiaqi Chen,Mengmeng Ni,Xinqin Ji

The Biochemical journal 476:3081-3107 PubMed31665227

2019

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44.

Applications

Unspecified application

Species

Unspecified reactive species

Nazma Malik,Raja S Nirujogi,Julien Peltier,Thomas Macartney,Melanie Wightman,Alan R Prescott,Robert Gourlay,Matthias Trost,Dario R Alessi,Athanasios Karapetsas

View all publications

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Anti-Syntaxin-5抗体

Anti-Syntaxin-5 antibody

Immunoprecipitation - Anti-Syntaxin-5 antibody (AB217130)