AB178415

重组Anti-Syncollin抗体[EPRR13148]

Anti-Syncollin antibody [EPRR13148]

RabMAb
Recombinant
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(4 Publications)

Rabbit Recombinant Monoclonal Syncollin antibody. Suitable for WB and reacts with Human, Rat, Mouse samples. Cited in 4 publications.

查看别名

INSSA1, SYL, SYCN, Syncollin, Insulin synthesis-associated protein 1

1 Images

Supplier Data

Western blot - Anti-Syncollin antibody [EPRR13148] (AB178415)

All lanes:

Western blot - Anti-Syncollin antibody [EPRR13148] (ab178415) at 1/1000 dilution

Lane 1:

Fetal pancreas lysate at 10 µg

Lane 2:

Rat pancreas lysate at 10 µg

Lane 3:

Mouse pancreas lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 14 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-Syncollin antibody [EPRR13148] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPRR13148

亚型

IgG

不含载体蛋白

反应种属

Mouse, Rat, Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯度

Tissue culture supernatant

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Syncollin also known as SYCN is a protein with a molecular mass of approximately 13 kDa. It is expressed mainly in the pancreatic acinar cells. Syncollin has critical involvement in the regulation of secretory pathways in the pancreas. Its primary role involves anchoring to the membranes of secretory granules which assists in the controlled release of digestive enzymes. Through its interaction with lipid environments Syncollin maintains stability and functionality of these granules ensuring efficient secretion processes.

Biological function summary

Syncollin contributes to the optimization of exocrine pancreatic functions. It acts within a complex that involves membrane-bound and cytosolic proteins which together facilitate the exocytosis of granules. Syncollin’s specific membrane-binding motif enhances its ability to anchor granules effectively increasing the precision of enzyme release. The protein's interaction with other cellular components supports the structural integrity of secretory vesicles impacting digestive enzyme distribution and activity.

Pathways

Syncollin plays a role in exocytosis and related signaling pathways. It interacts with proteins such as Rab3D which regulates vesicle docking and fusion. It is also implicated in pathways involving synaptotagmin which controls vesicular membrane fusion dynamics. Syncollin’s involvement in these pathways highlights its role in coordinating the timing and specificity of enzyme secretion which is essential for maintaining digestive processes in response to physiological cues.

Dysfunction in Syncollin correlates with pancreatitis where impaired secretory activity contributes to inflammation. Additionally Syncollin has potential connections to cystic fibrosis where aberrant secretory processes affect tissue health. The interaction of Syncollin with proteins like CFTR a cystic fibrosis transmembrane conductance regulator might influence the progression of these conditions suggesting possible targets for therapeutic intervention. Understanding the role of Syncollin in these disorders provides insights for developing strategies to manage pancreatic dysfunction.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity).

See full target information SYCN

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:1702 PubMed39962054

2025

Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Jana Marielle Modenbach,Christina Möller,Saeedeh Asgarbeik,Norman Geist,Niklas Rimkus,Mark Dörr,Hannes Wolfgramm,Leif Steil,Anne Susemihl,Leonie Graf,Ole Schmöker,Dominique Böttcher,Elke Hammer,Juliane Glaubitz,Michael Lammers,Mihaela Delcea,Uwe Völker,Ali Alexander Aghdassi,Markus M Lerch,Frank Ulrich Weiss,Uwe T Bornscheuer,Matthias Sendler

Cellular and molecular life sciences : CMLS 81:207 PubMed38709385

2024

Initiation of acute pancreatitis in mice is independent of fusion between lysosomes and zymogen granules.

Applications

Unspecified application

Species

Unspecified reactive species

Lukas Zierke,Daniel John,Marcel Gischke,Quang Trung Tran,Matthias Sendler,Frank Ulrich Weiss,Uwe T Bornscheuer,Christoph Ritter,Markus M Lerch,Ali A Aghdassi

Nature communications 11:4286 PubMed32855403

2020

Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas.

Applications

Unspecified application

Species

Unspecified reactive species

Janaki N Sudhakar,Hsueh-Han Lu,Hung-Yu Chiang,Ching-Shu Suen,Ming-Jing Hwang,Sung-Yu Wu,Chia-Ning Shen,Yao-Ming Chang,Fu-An Li,Fu-Tong Liu,Jr-Wen Shui

Gastroenterology 154:704-718.e10 PubMed29079517

2018

Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Matthias Sendler,Frank-Ulrich Weiss,Janine Golchert,Georg Homuth,Cindy van den Brandt,Ujjwal M Mahajan,Lars-Ivo Partecke,Paula Döring,Ilya Gukovsky,Anna S Gukovskaya,Preshit R Wagh,Markus M Lerch,Julia Mayerle

View all publications

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重组Anti-Syncollin抗体[EPRR13148]