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AB271345

重组Anti-Surfactant蛋白B (Mature)抗体[RM370]

Anti-Surfactant Protein B antibody [RM370]

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(6 Publications)

Rabbit Recombinant Monoclonal PSPB antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human SFTPB.

查看别名

SFTP3, SFTPB, Pulmonary surfactant-associated protein B, SP-B, 18 kDa pulmonary-surfactant protein, 6 kDa protein, Pulmonary surfactant-associated proteolipid SPL(Phe)

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Surfactant Protein B antibody [RM370] (AB271345)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Surfactant Protein B antibody [RM370] (AB271345)

Formalin-fixed, paraffin embedded human lung cancer tissue stained for Surfactant Protein B using ab271345 at a 1/1000 dilution in immunohistochemical analysis.

Western blot - Anti-Surfactant Protein B antibody [RM370] (AB271345)
  • WB

Supplier Data

Western blot - Anti-Surfactant Protein B antibody [RM370] (AB271345)

All lanes:

Western blot - Anti-Surfactant Protein B antibody [RM370] (ab271345) at 1/1000 dilution

All lanes:

human lung tissue lysate

Predicted band size: 42 kDa

false

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

RM370

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB, IHC-P

applications

免疫原

Synthetic Peptide within Human SFTPB. The exact immunogen used to generate this antibody is proprietary information.

P07988

特异性

Reacts with human Surfactant Protein B and pro-Surfactant Protein B.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
Preservative: 0.09% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Surfactant Protein B often called "mature protein B" or SP-B plays a mechanical role in the lungs by stabilizing the alveoli during respiration. SP-B with a molecular mass of approximately 8 kDa is highly expressed in the epithelial cells of the alveoli in the pulmonary system. It serves as a critical component in the maintenance and function of pulmonary surfactant which reduces surface tension and prevents the collapse of alveoli during exhalation.
Biological function summary

Surfactant Protein B participates in lipid spreading and film formation at the air-water interface inside the alveoli. It functions as part of a protein-lipid complex mainly interacting with phospholipids to optimize the surface tension-lowering capabilities of the surfactant. This protein is essential for proper lung function from birth facilitating efficient gas exchange and preventing atelectasis or alveolar collapse.

Pathways

Surfactant Protein B is an important player in the pulmonary surfactant metabolism pathway. This pathway involves the synthesis secretion and recycling of surfactant components necessary for lung function. SP-B works alongside other surfactant proteins like Surfactant Protein C (SP-C) and SP-D to ensure the efficiency of surfactant composition and distribution allowing for normal respiratory processes and homeostasis in lung tissue.

Surfactant Protein B mutations or deficiencies lead to severe respiratory conditions such as Surfactant Protein B deficiency disorder in infants which can be life-threatening and require immediate clinical intervention. It links to conditions like neonatal respiratory distress syndrome where lack of SP-B disrupts alveolar surface tension balance. SP-B interacts with other surfactant proteins and phospholipids and disturbances in its function can exacerbate or prognosis for such disorders.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
See full target information SFTPB
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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Biomedicines 13: PubMed40722696

2025

Role of BMPR2 Mutation in Lung Organoid Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Simin Jiang,Dian Chen,Liangliang Tian,Zihang Pan,Huanyu Long,Lanhe Chu,Weijing Kong,Qiyang Yao,Xiaojing Ma,Yun Zhao,Kai Wang,Yahong Chen

Nature communications 16:6241 PubMed40624080

2025

Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses.

Applications

Unspecified application

Species

Unspecified reactive species

Huijun Dong,Zihang Pan,Pengtao Jiao,Fei Ye,Qi Peng,Yanying Yu,Xinyuan Lai,Huan Li,Zhao Guan,Juan Deng,Tao Shen,Wenjie Tan,Yi Shi,Qiang Ding,Jianyuan Luo,Tong Li,Hui Zhuang,Kuanhui Xiang

EBioMedicine 113:105626 PubMed40023045

2025

Bi-allelic LAMP3 variants in childhood interstitial lung disease: a surfactant-related disease.

Applications

Unspecified application

Species

Unspecified reactive species

Camille Louvrier,Tifenn Desroziers,Yohan Soreze,Martha Delgado Rodriguez,Lucie Thomas,Valérie Nau,Florence Dastot-Le Moal,Jonathan A Bernstein,F Sessions Cole,Markus Damme,Anthony Fischer,Matthias Griese,Daniel Hinds,Laura Keehan,Carlos Milla,Hadhud Mohammad,Jonathan Rips,Jennifer A Wambach,Daniel J Wegner,Serge Amselem,Marie Legendre,Irina Giurgea,Sonia Athina Karabina,Oded Breuer,Aurore Coulomb l'Herminé,Nadia Nathan

Cell death & disease 14:493 PubMed37532692

2023

Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Chan Xiang,Min Zhang,Zhanxian Shang,Shengnan Chen,Jikai Zhao,Bowen Ding,Dong Jiang,Qian Zhu,Haohua Teng,Lei Zhu,Jinchen Shao,Ruiying Zhao,Min Ye,Yang Yu,Yuchen Han

International journal of nanomedicine 18:641-657 PubMed36789391

2023

Gestational Diabetes Mellitus Impedes Fetal Lung Development Through Exosome-Dependent Crosstalk Between Trophoblasts and Lung Epithelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Pengzheng Chen,Mengqi Gu,Shuting Wan,Xiaotong Jiang,Fengyuan Zhang,Yuchen Li,Qian Zhou,Yuan Lu,Lei Li,Xietong Wang

Molecular neurobiology 59:3414-3430 PubMed35320455

2022

HDAC3 Inhibition Stimulates Myelination in a CMT1A Mouse Model.

Applications

Unspecified application

Species

Unspecified reactive species

Robert Prior,Stijn Verschoren,Katlijn Vints,Tom Jaspers,Elisabeth Rossaert,Yvonne E Klingl,Alessio Silva,Nicole Hersmus,Philip Van Damme,Ludo Van Den Bosch
View all publications
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