AB5316

Anti-Sumo 1抗体

Name: Sumo 1抗体 (ab5316)| Abcam中文官网
Brand: Abcam Limited
SKU: AB5316
Price: 5125 CNY
Availability: InStock
Rating: 4 (1 reviews)

Anti-Sumo 1 antibody

(1 Review)

(53 Publications)

Rabbit Polyclonal Sumo 1 antibody. Suitable for WB and reacts with Arabidopsis thaliana samples. Cited in 53 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Arabidopsis thaliana SUMO1.

查看别名

SMT3, SUM1, At4g26840, F10M23.180, SUMO1, Small ubiquitin-related modifier 1, AtSUMO1, Ubiquitin-like protein SMT3

1 Images

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Western blot - Anti-Sumo 1 antibody (AB5316)

Western blots of SUMO1 and SUMO3 antibody on arabidopsis extracts heat treated for the indicated times by moving them from 24 to 37 degrees C. The panel on the left was using ab5316, the panel on the right was using ab5317 - both antibodies were used at a dilution of 1/1000.

Lane 1:

Western blot - Anti-Sumo 3 antibody (<a href='/products/primary-antibodies/sumo-3-antibody-ab5317'>ab5317</a>)

Lane 1:

Western blot - Anti-Sumo 1 antibody (ab5316)

Predicted band size: 11 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Arabidopsis thaliana

应用

applications

免疫原

Recombinant Full Length Protein corresponding to Arabidopsis thaliana SUMO1.

P55852

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Arabidopsis thaliana": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯度

Whole antiserum

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SUMO 1 also known as small ubiquitin-like modifier 1 is part of the protein family involved in post-translational modification. The protein mechanically adds a SUMO group to target proteins through sumoylation a process similar to ubiquitination. SUMO 1 typically has a molecular mass of around 11 kDa. It expresses in various tissues and cells including the nucleus and cytoplasm of eukaryotic cells. In addition it is important in processes like nuclear transport transcriptional regulation and protein stabilization.

Biological function summary

SUMO 1 contributes significantly to maintaining cellular homeostasis. It is an integral part of a SUMOylation complex that modifies other proteins to alter their function localization or interactions. Through its modification actions SUMO 1 affects processes such as DNA repair and the cell cycle. By interacting with components of the nuclear pore complex and transcription factors SUMO 1 modulates essential biological activities at multiple levels within the cell.

Pathways

This protein plays a significant role in the PI3K/Akt pathway and Wnt signaling. SUMO 1 associates with proteins like RanGAP1 and various transcription factors highlighting the complexity of its regulatory actions. These associations are important for the regulation of cell survival proliferation and differentiation. SUMOylation by SUMO 1 has been linked to an interference with phosphorylation showing its potential influence on cell signaling pathways.

The dysregulation of SUMO 1 is seen in cancer and neurodegenerative diseases. For instance altered SUMOylation patterns contribute to the progression of certain cancers. Furthermore SUMO 1 interacts with proteins like p53 and these interactions can affect tumor suppression and cell cycle regulation. In neurodegenerative disorders disturbed SUMOylation is associated with protein aggregation and neuronal damage implicating SUMO 1 in diseases like Alzheimer's.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Required for the massive protein sumoylation in the nucleus induced by heat shock and controlled by SIZ1. Involved in the regulation of the heat stress transcription factor HSFA2 in acquired thermotolerance.

See full target information SUMO1

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文献 (53)

Recent publications for all applications. Explore the full list and refine your search

Cellular oncology (Dordrecht, Netherlands) : PubMed41051595

2025

TAK-981 potentiates doxorubicin immunocide in triple-negative breast cancer by IFN I-dependent NK cell stimulation.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Liu,Yiming Wang,Xiaoxia Wei,Suyan Liu,Congting Hu,Pingping Peng,Wenhua Wu,Jiaqin Cai,Hong Sun

Science advances 11:eadt1891 PubMed40106541

2025

A KNOTTED1-LIKE HOMEOBOX PROTEIN1-interacting transcription factor SlGATA6 maintains the auxin-response gradient to inhibit abscission.

Applications

Unspecified application

Species

Unspecified reactive species

Xianfeng Liu,Lina Cheng,Yue Cai,Yang Liu,Xuemei Yan,Jiayun Liu,Ruizhen Li,Siqi Ge,Sai Wang,Xingan Liu,Sida Meng,Mingfang Qi,Cai-Zhong Jiang,Tianlai Li,Tao Xu

BMC plant biology 24:1192 PubMed39701969

2024

Definition and regulatory analysis of the SUMOylation system in Caixin (Brassica rapa var. Parachinensis) during pectobacterium carotovorum infection.

Applications

Unspecified application

Species

Unspecified reactive species

Shikang Lei,Guangguang Li,Ding Jiang,Fanchong Yuan,Yansong Zheng,Bihao Cao,Hua Zhang

The New phytologist 245:1040-1055 PubMed39562527

2024

SUMOylation of AL6 regulates seed dormancy and thermoinhibition in Arabidopsis.

Applications

Unspecified application

Species

Unspecified reactive species

Hua Jing,Wei Liu,Gao-Ping Qu,De Niu,Jing Bo Jin

Cancers 16: PubMed39410013

2024

Combined PET Radiotracer Approach Reveals Insights into Stromal Cell-Induced Metabolic Changes in Pancreatic Cancer In Vitro and In Vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Alina Doctor,Markus Laube,Sebastian Meister,Oliver C Kiss,Klaus Kopka,Sandra Hauser,Jens Pietzsch

The plant genome 17:e20511 PubMed39291540

2024

Functional characterization of protein SUMOylation in the miRNA transcription regulation during heat stress in Arabidopsis.

Applications

Unspecified application

Species

Unspecified reactive species

Simin Xia,Yue Chen,Jianbin Lai,Zhonghui Zhang,Chengwei Yang,Danlu Han

Plant physiology 195:1601-1623 PubMed38497423

2024

E3 SUMO ligase SIZ1 splicing variants localize and function according to external conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Soo Kwak,Jong Tae Song,Hak Soo Seo

Antioxidants (Basel, Switzerland) 12: PubMed38001832

2023

Endothelial Notch Signaling Regulates the Function of the Retinal Pigment Epithelial Barrier via EC Angiocrine Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yali Niu,Yixuan Xi,Yutong Jing,Ziyi Zhou,Xiaojia Sun,Guoheng Zhang,Tianhao Yuan,Tianfang Chang,Guorui Dou

Plant direct 7:e506 PubMed37465357

2023

-expressing lysine-null SUMO1 reveals a non-essential role for secondary SUMO modifications in plants.

Applications

Unspecified application

Species

Unspecified reactive species

Thérèse C Rytz,Juanjuan Feng,Jessica A S Barros,Richard D Vierstra

The Plant cell 35:3889-3910 PubMed37399070

2023

Thermosensitive SUMOylation of TaHsfA1 defines a dynamic ON/OFF molecular switch for the heat stress response in wheat.

Applications

Unspecified application

Species

Unspecified reactive species

Haoran Wang,Man Feng,Yujie Jiang,Dejie Du,Chaoqun Dong,Zhaoheng Zhang,Wenxi Wang,Jing Liu,Xiangqing Liu,Sufang Li,Yongming Chen,Weilong Guo,Mingming Xin,Yingyin Yao,Zhongfu Ni,Qixin Sun,Huiru Peng,Jie Liu

View all publications

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Anti-Sumo 1抗体

Anti-Sumo 1 antibody

Western blot - Anti-Sumo 1 antibody (AB5316)