AB69678

Anti-STK31抗体

Anti-STK31 antibody

(1 Review)

(2 Publications)

Mouse Polyclonal STK31 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human STK31.

查看别名

SGK396, STK31, Serine/threonine-protein kinase 31, Serine/threonine-protein kinase NYD-SPK, Sugen kinase 396, SgK396

1 Images

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Western blot - Anti-STK31 antibody (AB69678)

All lanes:

Western blot - Anti-STK31 antibody (ab69678) at 1/500 dilution

Lane 1:

STK31 transfected 293T lysate at 25 µg

Lane 2:

Non-transfected 293T lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Predicted band size: 116 kDa

Observed band size: 130 kDa

false

关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

Yes

反应种属

Human

应用

applications

免疫原

Recombinant Full Length Protein corresponding to Human STK31.

Q9BXU1

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein G

存储溶液

pH: 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

STK31 also known as Serine/Threonine Kinase 31 or TDRD8 is a protein kinase involved in phosphorylation processes. This protein has a molecular weight of approximately 67 kDa. It is mostly expressed in testicular tissue where it contributes to germ cell development. The expression of STK31 might vary depending on the developmental stage and cellular environment suggesting a role in reproductive biology.

Biological function summary

The activity of STK31 impacts cellular processes critical for germ cell maturation and division. STK31 interacts within complex networks of proteins and possibly forms part of a larger protein complex involved in orchestrating cell cycle progression. Its enzymatic role aids in regulating checkpoints during cell division ensuring proper cellular replication and integrity within reproductive tissues.

Pathways

The role of STK31 is significant in the regulation of the cell cycle and PI3K/AKT signaling pathways. This kinase participates in signaling cascades that control cell proliferation and survival aligning with its primary function in germ cells. STK31's activity relates to other proteins in these pathways such as CDK and AKT which mediate various aspects of cellular growth and replication helping maintain balance and function in cellular contexts.

STK31 has connections to germ cell tumors and testicular cancer. Aberrant expression or mutations of STK31 are associated with testicular germ cell tumors indicating its critical role in normal and pathological conditions. It shares a link with proteins like OCT4 and NANOG which are known for roles in stem cell pluripotency and are found deregulated in certain cancers implicating STK31 in oncogenic processes within reproductive tissues.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information STK31

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Proceedings of the National Academy of Sciences of the United States of America 117:19408-19414 PubMed32719138

2020

CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression.

Applications

Unspecified application

Species

Unspecified reactive species

Michael P Crawford,Sushmita Sinha,Pranav S Renavikar,Nicholas Borcherding,Nitin J Karandikar

Oncology reports 43:395-404 PubMed31894338

2020

STK31 regulates the proliferation and cell cycle of lung cancer cells via the Wnt/β‑catenin pathway and feedback regulation by c‑myc.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Xiong,Shigang Xing,Zheng Dong,Lei Niu,Qinghua Xu,Pingyi Liu,Peixia Yang

View all publications

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Anti-STK31抗体

Anti-STK31 antibody

Western blot - Anti-STK31 antibody (AB69678)