Anti-STEAP3抗体(ab126068)
Key features and details
- Rabbit polyclonal to STEAP3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-STEAP3抗体
参阅全部 STEAP3 一抗 -
描述
兔多克隆抗体to STEAP3 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
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免疫原
Recombinant fragment, corresponding to a region within amino acids 1-218 of Human STEAP3 (Q658P3).
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阳性对照
- HepG2 whole cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab126068于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (1) |
1/500 - 1/3000. Predicted molecular weight: 54 kDa.
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| 说明 |
|---|
|
WB
1/500 - 1/3000. Predicted molecular weight: 54 kDa. |
靶标
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功能
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. -
组织特异性
Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. -
疾病相关
Anemia, hypochromic microcytic, with iron overload 2 -
序列相似性
Belongs to the STEAP family.
Contains 1 ferric oxidoreductase domain. -
翻译后修饰
Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner.
Glycosylated. -
细胞定位
Endosome membrane. Localizes to vesicular-like structures at the plasma membrane and around the nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 55240 Human
- Entrez Gene: 68428 Mouse
- Entrez Gene: 170824 Rat
- Omim: 609671 Human
- SwissProt: Q658P3 Human
- SwissProt: Q8CI59 Mouse
- SwissProt: Q5RKL5 Rat
- Unigene: 647822 Human
see all -
别名
- 1010001D01Rik antibody
- Dudlin 2 antibody
- Dudlin2 antibody
see all
图片
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Western blot - Anti-STEAP3 antibody (ab126068)Anti-STEAP3 antibody (ab126068) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg
Predicted band size: 54 kDa
10% SDS PAGE
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab126068 尚未被引用在任何文献中。