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AB207914

Anti-STEAP1抗体[J2D2] - N-terminal

Anti-STEAP1 antibody [J2D2] - N-terminal

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(5 Publications)

Mouse Monoclonal STEAP1 antibody. N-terminal. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STEAP1 aa 1-100.

查看别名

PRSS24, STEAP, STEAP1, STEAP1 protein, Six-transmembrane epithelial antigen of prostate 1

1 Images
Western blot - Anti-STEAP1 antibody [J2D2] - N-terminal (AB207914)
  • WB

Supplier Data

Western blot - Anti-STEAP1 antibody [J2D2] - N-terminal (AB207914)

All lanes:

Western blot - Anti-STEAP1 antibody [J2D2] - N-terminal (ab207914) at 1/1000 dilution

All lanes:

U-87 MG (human glioblastoma-astrocytoma epithelial cell line) cell lysate at 40 µg

Secondary

All lanes:

Goat Anti-mouse secondary antibody (HRP)

Predicted band size: 40 kDa

true

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

J2D2

亚型

IgG2b

轻链类型

kappa

不含载体蛋白

No

反应种属

Human

应用

WB

applications

免疫原

Recombinant Fragment Protein within Human STEAP1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9UHE8

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搭配使用产品

Proteins & Peptides

AB162041

Recombinant Human STEAP1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human STEAP1 protein (GST tag N-Terminus) (AB162041)

  • 0
  • 0
Primary Antibodies

AB133579

Anti-PSMA antibody [EPR6253]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PSMA antibody [EPR6253] (AB133579)

  • 3
  • 2
Primary Antibodies

AB33911

Anti-Cyclin E1 antibody [EP435E]

20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Cyclin E1 antibody [EP435E] (AB33911)

  • 4
  • 8
Primary Antibodies

AB76113

Anti-Prostate Specific Antigen antibody [EP1588Y]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostate Specific Antigen antibody [EP1588Y] (AB76113)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }
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产品详情

This product was changed from ascites to tissue culture supernatant on 20th Jan 2020. Lot numbers higher than GR325188 are from tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
纯化说明
By protein-A affinity chromatography
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 10% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

STEAP1 also known as Six Transmembrane Epithelial Antigen of the Prostate 1 is a plasma membrane protein with a molecular weight around 50 kDa. This protein is expressed primarily in prostate tissues but also in a variety of other epithelial tissues. It plays a mechanical role as a metalloreductase facilitating the reduction of metal ions such as iron and copper across the cell membrane. STEAP1 features a characteristic six transmembrane domain which is important for its activity and localization.
Biological function summary

STEAP1 impacts cellular processes connected to metal ion homeostasis and proliferation. By performing as a metalloreductase it modulates the redox state and availability of metal ions within cells. STEAP1 functions as part of a larger complex interacting with other transmembrane proteins in the regulation of ion transport and reduction reactions. These roles are significant in maintaining cellular metabolism and oxidative balance.

Pathways

STEAP1 is actively involved in pathways related to iron and copper metabolism. It links to the iron uptake and transport pathways ensuring proper cellular iron levels are maintained. STEAP1 also shares functional relationships with proteins such as ferritin which stores iron and transferrin which transports iron in the bloodstream. STEAP1 therefore plays an important part in connecting cellular metabolism to systemic metal homeostasis.

STEAP1 has notable associations with prostate cancer and Ewing's sarcoma. Elevated expression of STEAP1 often correlates with the progression of prostate cancer hinting at a potential role in tumor growth and survival. In Ewing's sarcoma STEAP1 engages in molecular mechanisms related to the disease's pathology. Interaction with proteins such as PCA3 a prostate cancer antigen underlines its involvement in carcinogenic processes and highlights its potential as a therapeutic target in oncology.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4.
See full target information STEAP1
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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Journal of bone oncology 37:100458 PubMed36388640

2022

EFEMP1 binds to STEAP1 to promote osteosarcoma proliferation and invasion via the Wnt/β-catenin and TGF-β/Smad2/3 signal pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Dong Zhang,Shasha Han,Xin Pan,Hao Li,Hua Zhao,Xianlei Gao,Songgang Wang

Frontiers in immunology 13:940093 PubMed36203611

2022

IL-10 partly mediates the ability of MSC-derived extracellular vesicles to attenuate myocardial damage in experimental metabolic renovascular hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Yamei Jiang,Siting Hong,Xiangyang Zhu,Lei Zhang,Hui Tang,Kyra L Jordan,Ishran M Saadiq,Weijun Huang,Amir Lerman,Alfonso Eirin,Lilach O Lerman

World journal of surgical oncology 20:96 PubMed35346237

2022

Expression and prognostic analyses of the significance of STEAP1 and STEAP2 in lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Tianshu Liu,Xiaoxin Niu,Yanqing Li,Zekun Xu,Jie Chen,Geng Xu

Journal of cellular and molecular medicine : PubMed33128353

2020

A research of STEAP1 regulated gastric cancer cell proliferation, migration and invasion in vitro and in vivos.

Applications

Unspecified application

Species

Unspecified reactive species

Zhe Zhang,Wen-Bin Hou,Chao Zhang,Yu-En Tan,Dong-Dong Zhang,Wen An,Si-Wei Pan,Wan-di Wu,Qing-Chuan Chen,Hui-Mian Xu

Clinical breast cancer 19:e195-e207 PubMed30253922

2018

STEAP1 Inhibits Breast Cancer Metastasis and Is Associated With Epithelial-Mesenchymal Transition Procession.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Xie,Yan Yang,Jiali Sun,Zhi Jiao,Haozheng Zhang,Jie Chen
View all publications
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