Anti-SRRM2抗体(ab122719)
Key features and details
- Rabbit polyclonal to SRRM2
- Suitable for: ICC, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SRRM2抗体
参阅全部 SRRM2 一抗 -
描述
兔多克隆抗体to SRRM2 -
宿主
Rabbit -
经测试应用
适用于: ICC, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Recombinant Protein Epitope Signature Tag antigen, corresponding to amino acids 1098 - 1203 of Human SRRM2 Isoforms 1 and 2 (Q9UQ35). Note: this sequence is missing in Isoform 3.
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阳性对照
- ICC: Human cell line U-2 OS; IHC-P: Human small intestine, endometrium, cerebral cortex, and skin tissues.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab122719于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC |
Use a concentration of 0.25 - 2 µg/ml.
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| IHC-P | (1) |
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| 说明 |
|---|
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ICC
Use a concentration of 0.25 - 2 µg/ml. |
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IHC-P
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA. -
组织特异性
Expressed in liver, placenta, and white blood cells. -
序列相似性
Belongs to the CWC21 family. -
翻译后修饰
Phosphorylated upon DNA damage, probably by ATM or ATR. -
细胞定位
Nucleus speckle. - Information by UniProt
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数据库链接
- Entrez Gene: 23524 Human
- Omim: 606032 Human
- SwissProt: Q9UQ35 Human
- Unigene: 433343 Human
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别名
- 300 kDa nuclear matrix antigen antibody
- CWC21 antibody
- KIAA0324 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SRRM2 antibody (ab122719)
Immunohistochemistry analysis of human small intestine tissue with ab122719 at 1/1000. Heat mediated antigen retrieval performed at pH 6.
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Immunocytochemistry - Anti-SRRM2 antibody (ab122719)ab122719, at 4 ug/ml, staining SRRM2 in Human cell line U-2 OS by Immunoflouroscence. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SRRM2 antibody (ab122719)Immunohistochrmistry analysis of human skin tissue with ab122719 at 1/1000. Heat mediated antigen retrieval performed at pH 6.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SRRM2 antibody (ab122719)Immunohistochrmistry analysis of human endometrium tissue with ab122719 at 1/1000. Heat mediated antigen retrieval performed at pH 6.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SRRM2 antibody (ab122719)Immunohistochrmistry analysis of human cerebral cortex tissue with ab122719 at 1/1000. Heat mediated antigen retrieval performed at pH 6.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab122719 被引用在 3 文献中.
- Vihola A et al. Novel mutation in TNPO3 causes congenital limb-girdle myopathy with slow progression. Neurol Genet 5:e337 (2019). PubMed: 31192305
- Tanaka H et al. The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. Mol Psychiatry 23:2090-2110 (2018). PubMed: 30283027
- Bai B et al. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Proc Natl Acad Sci U S A 110:16562-7 (2013). IHC-FrFl ; Human . PubMed: 24023061