AB124958

Anti-srGAP2 抗体 [EP2506(2)]

Name: srGAP2抗体[EP2506(2)] (ab124958)| Abcam中文官网
Brand: Abcam Limited
SKU: AB124958
Price: 2279 CNY
Availability: InStock
Rating: 3 (2 reviews)

Anti-srGAP2 antibody [EP2506(2)]

RabMAb
Recombinant
了解详情

(2 Reviews)

(3 Publications)

Rabbit Recombinant Monoclonal srGAP2 antibody. Suitable for WB and reacts with Mouse, Human, Rat samples. Cited in 3 publications.

查看别名

ARHGAP34, FNBP2, KIAA0456, SRGAP2A, SRGAP2, SLIT-ROBO Rho GTPase-activating protein 2, srGAP2, Formin-binding protein 2, Rho GTPase-activating protein 34

2 Images

Supplier Data

Western blot - Anti-srGAP2 antibody [EP2506(2)] (AB124958)

Blocking and diluting buffer and concentration : 5% NFDM/TBST.

All lanes:

Western blot - Anti-srGAP2 antibody [EP2506(2)] (ab124958) at 1/1000 dilution

All lanes:

HEK-293 (Human embryonic kidney epithelial cell) whole cell lysate at 15 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Observed band size: 140 kDa

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Supplier Data

Western blot - Anti-srGAP2 antibody [EP2506(2)] (AB124958)

Blocking and diluting buffer and concentration : 5% NFDM/TBST.

All lanes:

Western blot - Anti-srGAP2 antibody [EP2506(2)] (ab124958) at 1/1000 dilution

Lane 1:

Mouse brain lysate at 20 µg

Lane 2:

Rat brain lysate at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Observed band size: 140 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-srGAP2 antibody [EP2506(2)] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EP2506(2)

亚型

IgG

不含载体蛋白

反应种属

Mouse, Rat, Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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产品详情

This product has switched from a hybridoma to recombinant production method on 7th September 2023.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

储存信息

Stable for 12 months at -20°C

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed : 20810653, PubMed : 27373832, PubMed : 28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed : 22559944, PubMed : 27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed : 27373832). Promotes cell repulsion and contact inhibition of locomotion : localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed : 20810653, PubMed : 21148482).

See full target information SRGAP2

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Neuron 112:3602-3617.e9 PubMed39406239

2024

Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Baptiste Libé-Philippot,Ryohei Iwata,Aleksandra J Recupero,Keimpe Wierda,Sergio Bernal Garcia,Luke Hammond,Anja van Benthem,Ridha Limame,Martyna Ditkowska,Sofie Beckers,Vaiva Gaspariunaite,Eugénie Peze-Heidsieck,Daan Remans,Cécile Charrier,Tom Theys,Franck Polleux,Pierre Vanderhaeghen

Cell reports 40:111358 PubMed36130489

2022

A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-β2 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Chandrani Mondal,Majo J Gacha-Garay,Kathryn A Larkin,Rebecca C Adikes,Julie S Di Martino,Chen-Chi Chien,Madison Fraser,Ireti Eni-Aganga,Esperanza Agullo-Pascual,Katarzyna Cialowicz,Umut Ozbek,Alexandra Naba,Angelo Gaitas,Tian-Ming Fu,Srigokul Upadhyayula,Eric Betzig,David Q Matus,Benjamin L Martin,Jose Javier Bravo-Cordero

Molecular biology and evolution 34:1463-1478 PubMed28333212

2017

Structural History of Human SRGAP2 Proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Michael Sporny,Julia Guez-Haddad,Annett Kreusch,Sivan Shakartzi,Avi Neznansky,Alice Cross,Michail N Isupov,Britta Qualmann,Michael M Kessels,Yarden Opatowsky

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-srGAP2 抗体 [EP2506(2)]