Anti-Sprouty 4/Spry-4抗体(ab59785)
Key features and details
- Rabbit polyclonal to Sprouty 4/Spry-4
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Sprouty 4/Spry-4抗体
参阅全部 Sprouty 4/Spry-4 一抗 -
描述
兔多克隆抗体to Sprouty 4/Spry-4 -
宿主
Rabbit -
特异性
This antibody reacts specifically with human 32 kDa Sprouty 4/Spry-4 protein.
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经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Chicken, Cow
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免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
Constituent: Whole serum -
Concentration information loading... -
纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab59785于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (1) |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
WB
Use at an assay dependent concentration. |
靶标
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功能
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. -
序列相似性
Belongs to the sprouty family.
Contains 1 SPR (sprouty) domain. -
结构域
The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles. -
细胞定位
Cytoplasm. Cell projection > ruffle membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 427643 Chicken
- Entrez Gene: 504593 Cow
- Entrez Gene: 81848 Human
- Entrez Gene: 24066 Mouse
- Omim: 607984 Human
- SwissProt: A2VDU1 Cow
- SwissProt: Q9C004 Human
- SwissProt: Q9WTP2 Mouse
see all -
别名
- Protein sprouty homolog 4 antibody
- Sprouty 4 antibody
- Sprouty homolog 4 antibody
see all
数据表及文件
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Datasheet download
文献 (5)
ab59785 被引用在 5 文献中.
- Guo J et al. SPRY4 suppresses proliferation and induces apoptosis of colorectal cancer cells by repressing oncogene EZH2. Aging (Albany NY) 13:11665-11677 (2021). PubMed: 33879635
- Chai Z et al. miR-1908 as a novel prognosis marker of glioma via promoting malignant phenotype and modulating SPRY4/RAF1 axis. Oncol Rep 38:2717-2726 (2017). PubMed: 29048686
- Edmonds MD et al. MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer. J Clin Invest 126:349-64 (2016). PubMed: 26657862
- Lee JY et al. Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem Cells. Dev Reprod 20:171-7 (2016). WB . PubMed: 27660833
- Barbáchano A et al. SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity. Oncogene 29:4800-13 (2010). WB ; Human . PubMed: 20543868
