Anti-SPHK1抗体(ab61148)
Key features and details
- Rabbit polyclonal to SPHK1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SPHK1抗体
参阅全部 SPHK1 一抗 -
描述
兔多克隆抗体to SPHK1 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human SPHK1 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH).
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阳性对照
- Adrenal tissue (pheochromocytes).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.70
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab61148于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use a concentration of 10 µg/ml.
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| 说明 |
|---|
|
IHC-P
Use a concentration of 10 µg/ml. |
靶标
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功能
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. -
组织特异性
Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. -
序列相似性
Contains 1 DAGKc domain. - Information by UniProt
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数据库链接
- Entrez Gene: 8877 Human
- Omim: 603730 Human
- SwissProt: Q9NYA1 Human
- Unigene: 68061 Human
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别名
- SK 1 antibody
- SK1 antibody
- Sphingosine kinase 1 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SPHK1 antibody (ab61148)Ab61148 (10ug/ml) staining human SPHK1 in human adrenal tissue (pheochromocytes) by immunohistochemistry using formalin fixed, paraffin embedded tissue.
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab61148 被引用在 5 文献中.
- Wu X et al. Inhibition of SphK1/S1P Signaling Pathway Alleviates Fibrosis and Inflammation of Rat Myocardium after Myocardial Infarction. Comput Math Methods Med 2022:5985375 (2022). PubMed: 35872958
- Shen W et al. LncRNA PSMG3AS1 promotes proliferation of non-small cell lung cancer cells by sponging miR-613 to upregulate SphK1. Cell Cycle 20:829-838 (2021). PubMed: 33849377
- Reichmann MT et al. Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets. J Clin Invest 131:N/A (2021). PubMed: 34128839
- Chen J et al. Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice. Oncotarget 9:15635-15649 (2018). PubMed: 29643998
- Chen MH et al. Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma. Oncotarget 6:23594-608 (2015). PubMed: 26090720