Anti-SPARC抗体(ab55847)
Key features and details
- Rabbit polyclonal to SPARC
- Suitable for: IHC, ELISA, WB
- Reacts with: Mouse, Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-SPARC抗体
参阅全部 SPARC 一抗 -
描述
兔多克隆抗体to SPARC -
宿主
Rabbit -
经测试应用
适用于: IHC, ELISA, WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Synthetic peptide derived from the human SPARC protein.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.08% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯化说明
Purified by SAS precipitation. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab55847于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC |
Use at an assay dependent concentration.
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| ELISA |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration. Predicted molecular weight: 35 kDa.
PubMed: 19509023. |
| 说明 |
|---|
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IHC
Use at an assay dependent concentration. |
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ELISA
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 35 kDa. PubMed: 19509023. |
靶标
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功能
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. -
序列相似性
Belongs to the SPARC family.
Contains 1 EF-hand domain.
Contains 1 follistatin-like domain.
Contains 1 Kazal-like domain. -
发展阶段
Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair. -
细胞定位
Secreted > extracellular space > extracellular matrix > basement membrane. In or around the basement membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 6678 Human
- Entrez Gene: 20692 Mouse
- Omim: 182120 Human
- SwissProt: P09486 Human
- SwissProt: P07214 Mouse
- Unigene: 111779 Human
- Unigene: 708558 Human
- Unigene: 291442 Mouse
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别名
- AA517111 antibody
- Basement membrane protein 40 antibody
- Basement-membrane protein 40 antibody
see all
数据表及文件
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Datasheet download
文献 (11)
ab55847 被引用在 11 文献中.
- Hatori T et al. SPARC is a decoy counterpart for c‑Fos and is associated with osteoblastic differentiation of bone marrow stromal cells by inhibiting adipogenesis. Mol Med Rep 27:N/A (2023). PubMed: 36633137
- Ouyang B et al. Albumin-based formononetin nanomedicines for lung injury and fibrosis therapy via blocking macrophage pyroptosis. Mater Today Bio 20:100643 (2023). PubMed: 37214555
- Ming G et al. Identification and evaluation of fructose-bisphosphate aldolase B as a potential diagnostic biomarker in choledochal cysts patients: a quantitative proteomic analysis. Transl Pediatr 10:2083-2094 (2021). PubMed: 34584879
- Kalashnikova I et al. Ceria-based nanotheranostic agent for rheumatoid arthritis. Theranostics 10:11863-11880 (2020). PubMed: 33204316
- Xu J et al. Differential Protein Expression between Cystic and Solid Vestibular Schwannoma Using Tandem Mass Tag-Based Quantitative Proteomic Analysis. Proteomics Clin Appl 14:e1900112 (2020). PubMed: 32157794
