重组Anti-SOX18抗体[EPR2837(2)] (ab109194)
![Western blot - Anti-SOX18 antibody [EPR2837(2)] (ab109194)](https://www.abcam.cn/ps/products/109/ab109194/Images/ab109194-121810-anti-sox18-antibody-epr28372-western-blot.jpg "Western blot - Anti-SOX18 antibody [EPR2837(2)] (ab109194)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR2837(2)] to SOX18
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-SOX18抗体[EPR2837(2)]
参阅全部 SOX18 一抗 -
描述
兔单克隆抗体[EPR2837(2)] to SOX18 -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,ICC/IF,IHC-P or IP -
种属反应性
与反应: Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- K562, Human stomach, Jurkat, and HeLa cell lysates
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 0.05% BSA, 59% PBS -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR2837(2) -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab109194于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/1000 - 1/10000. Detects a band of approximately 41 kDa (predicted molecular weight: 41 kDa).
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| 说明 |
|---|
|
WB
1/1000 - 1/10000. Detects a band of approximately 41 kDa (predicted molecular weight: 41 kDa). |
应用说明
Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
靶标
-
功能
Binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site. -
疾病相关
Defects in SOX18 are the cause of hypotrichosis-lymphedema-telangiectasia syndrome (HLTS) [MIM:607823]. -
序列相似性
Contains 1 HMG box DNA-binding domain.
Contains 1 Sox C-terminal domain. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 54345 Human
- Omim: 601618 Human
- SwissProt: P35713 Human
- Unigene: 8619 Human
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别名
- HLTS antibody
- SOX 18 antibody
- Sox18 antibody
see all
图片
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Western blot - Anti-SOX18 antibody [EPR2837(2)] (ab109194)All lanes : Anti-SOX18 antibody [EPR2837(2)] (ab109194) at 1/1000 dilution
Lane 1 : K562 cell lysate
Lane 2 : Human stomach cell lysate
Lane 3 : Jurkat cell lysate
Lane 4 : HeLa cell lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 41 kDa
Observed band size: 41 kDa -
![Anti-SOX18 antibody [EPR2837(2)] (ab109194)](https://www.abcam.cn/ps/products/109/ab109194/Images/ab109194-2-benefits-of-recombinant-antibodies.png)
Anti-SOX18 antibody [EPR2837(2)] (ab109194)
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab109194 被引用在 3 文献中.
- Chen C et al. SUMOylation promotes extracellular vesicle-mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer. J Clin Invest 131:N/A (2021). PubMed: 33661764
- Xu Y et al. Down-regulation of SOX18 inhibits laryngeal carcinoma cell proliferation, migration, and invasion through JAK2/STAT3 signaling. Biosci Rep 39:N/A (2019). PubMed: 31189744
- Miao Z et al. Upregulation of SOX18 in colorectal cancer cells promotes proliferation and correlates with colorectal cancer risk. Onco Targets Ther 11:8481-8490 (2018). PubMed: 30555240