Anti-SorLA/SORL1抗体(ab22814)
Key features and details
- Goat polyclonal to SorLA/SORL1
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SorLA/SORL1抗体
参阅全部 SorLA/SORL1 一抗 -
描述
山羊多克隆抗体to SorLA/SORL1 -
宿主
Goat -
经测试应用
适用于: ICC/IFmore details -
种属反应性
与反应: Human
预测可用于: Rat, Rabbit, Cow, Dog
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免疫原
Synthetic peptide corresponding to Human SorLA/SORL1 aa 2203-2214 (C terminal).
Sequence:TGFSDDVPMVIA
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阳性对照
- Mouse brain lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
ab22814 is purified by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab22814于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF |
Use a concentration of 10 µg/ml.
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| 说明 |
|---|
|
ICC/IF
Use a concentration of 10 µg/ml. |
靶标
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功能
Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. -
组织特异性
Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals. -
序列相似性
Belongs to the SORL1 family.
Contains 5 BNR repeats.
Contains 1 EGF-like domain.
Contains 6 fibronectin type-III domains.
Contains 11 LDL-receptor class A domains.
Contains 5 LDL-receptor class B repeats. -
翻译后修饰
The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 6653 Human
- Entrez Gene: 300652 Rat
- Omim: 602005 Human
- SwissProt: Q92673 Human
- SwissProt: Q9R0N2 Rat
- Unigene: 368592 Human
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别名
- C11orf32 antibody
- FLJ21930 antibody
- FLJ39258 antibody
see all
图片
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Immunocytochemistry/ Immunofluorescence - Anti-SorLA/SORL1 antibody (ab22814)
Immunocytochemistry/ Immunofluorescence of HepG2 staining SorLA/SORL1 using ab22814 at 10 μg/ml followed by Alexa Fluor 488 secondary antibody 2 μg/ml
The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 μg/ml) followed by Alexa Fluor 488 secondary antibody (2 μg/ml).
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Immunocytochemistry/ Immunofluorescence - Anti-SorLA/SORL1 antibody (ab22814)Immunocytochemistry/ Immunofluorescence of A431 staining SorLA/SORL1 using ab22814 at 10 μg/ml followed by Alexa Fluor 488 secondary antibody 2 μg/ml
The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 μg/ml) followed by Alexa Fluor 488 secondary antibody (2 μg/ml).
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab22814 尚未被引用在任何文献中。