Anti-SNTB2抗体(ab96295)
Key features and details
- Rabbit polyclonal to SNTB2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SNTB2抗体 -
描述
兔多克隆抗体to SNTB2 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Cow, Monkey
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免疫原
Recombinant fragment, corresponding to a region within amino acids 174 - 538 of Human SNTB2
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阳性对照
- 293T, A431, H1299, HeLa, HepG2 and Raji cells. OVCAR3 xenograft.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab96295于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/3000. Predicted molecular weight: 58 kDa.
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| IHC-P |
1/100 - 1/500.
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| 说明 |
|---|
|
WB
1/500 - 1/3000. Predicted molecular weight: 58 kDa. |
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IHC-P
1/100 - 1/500. |
靶标
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功能
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. -
组织特异性
Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed. -
序列相似性
Belongs to the syntrophin family.
Contains 1 PDZ (DHR) domain.
Contains 2 PH domains.
Contains 1 SU (syntrophin unique) domain. -
结构域
The PH 1 domain mediates the oligomerization in a calcium dependent manner.
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.
The SU domain binds calmodulin in a calcium-dependent manner. -
翻译后修饰
Phosphorylated. Partially dephosphorylated upon insulin stimulation. -
细胞定位
Membrane. Cytoplasmic vesicle > secretory vesicle membrane. Cell junction. Cytoplasm > cytoskeleton. Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction (By similarity). In insulinoma cell line, it is enriched in secretory granules. - Information by UniProt
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数据库链接
- Entrez Gene: 786534 Cow
- Entrez Gene: 6645 Human
- Entrez Gene: 20650 Mouse
- Entrez Gene: 689421 Rat
- Omim: 600027 Human
- SwissProt: Q13425 Human
- SwissProt: Q61235 Mouse
- Unigene: 461117 Human
see all -
别名
- Syntrophin like antibody
- 59 kDa dystrophin associated protein A1 basic component 2 antibody
- 59 kDa dystrophin-associated protein A1 basic component 2 antibody
see all
图片
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Western blot - Anti-SNTB2 antibody (ab96295)Anti-SNTB2 antibody (ab96295) at 1/3000 dilution + HepG2 whole cell lysate at 30 µg
Predicted band size: 58 kDa
7.5% SDS PAGE -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SNTB2 antibody (ab96295)ab96295, at 1/500 dilution, staining SNTB2 in paraffin-embedded OVCAR3 xenograft
数据表及文件
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SDS download
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Datasheet download
文献 (0)
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