AB130132

Anti-SLC6A8抗体

Name: SLC6A8抗体 (ab130132)| Abcam中文官网
Brand: Abcam Limited
SKU: AB130132
Price: 4606 CNY
Availability: InStock
Rating: 4 (1 reviews)

Anti-SLC6A8 antibody

(1 Review)

(1 Publication)

Goat Polyclonal SLC6A8 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC6A8 aa 150-250.

查看别名

Sodium- and chloride-dependent creatine transporter 1, CT1, Creatine transporter 1, Solute carrier family 6 member 8, SLC6A8

1 Images

Supplier Data

Western blot - Anti-SLC6A8 antibody (AB130132)

All lanes:

Western blot - Anti-SLC6A8 antibody (ab130132) at 0.1 µg/mL

All lanes:

Mouse Heart lysate at 35 µg

Predicted band size: 70 kDa

false

关键信息

宿主种属

Goat

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human, Mouse

应用

WB, IHC-P

applications

免疫原

Synthetic Peptide within Human SLC6A8 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

P48029

特异性

ab130132 is expected to recognize all reported isoforms (NP_005620.1; NP_001136277.1; NP_001136278.1).

style

left-column

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.3 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chinese hamster": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Guinea pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

存储溶液

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SLC6A8 also known as the creatine transporter 1 (CRT1) is a protein that mediates the transport of creatine across the plasma membrane. It belongs to the solute carrier family 6 (SLC6) and has a mass of approximately 70 kDa. You can find SLC6A8 expressed widely in the brain skeletal muscles heart and kidneys where it plays a fundamental role in cellular energy homeostasis. The protein operates by utilizing the sodium and chloride gradients to facilitate creatine uptake which is critical for energy storage and supply in cells.

Biological function summary

This protein provides creatine for phosphate buffering and energy recycling in tissues with high-energy demands. SLC6A8 forms part of a complex that collaborates closely with creatine kinase enzymes enabling the maintenance of ATP levels in energy-intensive cells. Creatine uptake is essential for maintaining energy balance and SLC6A8 ensures that cells receive an adequate supply of creatine for their needs.

Pathways

SLC6A8 plays an integral role in the creatine biosynthesis and transport pathway. Its proper functioning is important for pathways involving energy metabolism particularly the phosphocreatine shuttle which connects it with creatine kinases. SLC6A8 is also part of the broader metabolic network interacting with other transporters and proteins involved in cellular energy dynamics ensuring efficient regulation of energy resources within cells.

Disruptions in SLC6A8 function can lead to conditions such as creatine transporter deficiency and X-linked creatine deficiency syndrome. These conditions often result in impaired cognitive development seizures and muscle weakness primarily due to insufficient creatine transport into the brain and muscles. In these disorders SLC6A8's interaction with the creatine kinase and other related enzymes proves significant emphasizing the importance of its proper function in avoiding such energy metabolism disorders.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Creatine : sodium symporter which mediates the uptake of creatine (PubMed : 17465020, PubMed : 22644605, PubMed : 25861866, PubMed : 7945388, PubMed : 7953292, PubMed : 9882430). Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity).

See full target information SLC6A8

style

left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2309292 PubMed38666459

2024

Genetic Screening of Haploid Neural Stem Cells Reveals that Nfkbia and Atp2b4 are Key Regulators of Oxidative Stress in Neural Precursors.

Applications

Unspecified application

Species

Unspecified reactive species

Shaochen Nie,Wenhao Zhang,Xin Jin,Xiaoyan Li,Shengyi Sun,Yiding Zhao,Qingshen Jia,Luyuan Li,Yan Liu,Dayong Liu,Qian Gao

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SLC6A8抗体

Anti-SLC6A8 antibody

Western blot - Anti-SLC6A8 antibody (AB130132)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性

反应性数据

性能和储存信息

形式

纯化工艺

纯化说明

存储溶液

运输条件

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (1)

Abcam Product Promise

Anti-SLC6A8抗体

Anti-SLC6A8 antibody

Western blot - Anti-SLC6A8 antibody (AB130132)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性

替代产品

Primary Antibodies

搭配使用产品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

反应性数据

性能和储存信息

形式

纯化工艺

纯化说明

存储溶液

运输条件

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (1)

Abcam Product Promise