AB78066

Anti-SLC40A1 抗体

Name: SLC40A1抗体 (ab78066)| Abcam中文官网
Brand: Abcam Limited
SKU: AB78066
Price: 4691 CNY
Availability: InStock
Rating: 5 (3 reviews)

Anti-SLC40A1 antibody

(3 Reviews)

(35 Publications)

Rabbit Polyclonal SLC40A1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 35 publications. Immunogen corresponding to Synthetic Peptide within Human SLC40A1.

查看别名

FPN, FPN1, IREG1, SLC11A3, MSTP079, SLC40A1, Ferroportin, Ferroportin-1, Iron-regulated transporter 1, Solute carrier family 40 member 1

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC40A1 antibody (AB78066)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC40A1 antibody (AB78066)

ab78066, at 20μg/ml, staining SLC40A1 in human skeletal muscle by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

A heat induced antigen retrieval step was performed using pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC40A1 antibody (AB78066)

Negative control - immunohistochemical staining of paraffin embedded, formalin fixed, breast epithelium using ab78066 at 20 μg/mL.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC40A1 antibody (AB78066)

Immunohistochemical staining of paraffin embedded, formalin fixed, kidney renal tubular epithelium using ab78066 at 20 μg/mL.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P

applications

免疫原

Synthetic Peptide within Human SLC40A1. The exact immunogen used to generate this antibody is proprietary information.

Q9NP59

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "20 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SLC40A1 also known as ferroportin or solute carrier family 40 member 1 is a transmembrane protein which functions as an iron transporter. This protein plays a role in exporting iron from cells into the bloodstream. The molecular weight of SLC40A1 is approximately 62 kDa. It is highly expressed in cells involved in iron storage and metabolism such as enterocytes in the duodenum and macrophages which process senescent red blood cells.

Biological function summary

The function of this transporter is important for iron homeostasis in human body. SLC40A1 helps balance iron levels by moving iron across intestinal cells into the plasma. It does not function as part of a larger protein complex but its activity is controlled by hepcidin a hormone that degrades SLC40A1 and regulates iron flow into the circulation.

Pathways

SLC40A1 is essential in the iron homeostasis pathway and the hepcidin regulation pathway. These pathways ensure iron supply matches body demands. It is closely related to hepcidin due to their interactive roles in this regulatory system. Hepcidin binds to SLC40A1 leading to its internalization and degradation which decreases iron export.

Mutations in SLC40A1 can lead to diseases like hemochromatosis characterized by excessive iron accumulation and anemia as iron transport becomes inefficient. Through these conditions SLC40A1 connects to hepcidin where disruption in their interaction contributes to disease pathology. Managing SLC40A1 activity is therefore important for maintaining proper iron levels and preventing related health issues.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed : 15692071, PubMed : 22178646, PubMed : 22682227, PubMed : 24304836, PubMed : 29237594, PubMed : 29599243, PubMed : 30247984). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (PubMed : 22682227, PubMed : 29237594, PubMed : 32814342).

See full target information SLC40A1

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文献 (35)

Recent publications for all applications. Explore the full list and refine your search

Nutrients 17: PubMed39940407

2025

EGCG Alleviates DSS-Induced Colitis by Inhibiting Ferroptosis Through the Activation of the Nrf2-GPX4 Pathway and Enhancing Iron Metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Junzhou Chen,Conghui Yin,Yilong Zhang,Xin Lai,Chen Liu,Yuheng Luo,Junqiu Luo,Jun He,Bing Yu,Quyuan Wang,Huifen Wang,Daiwen Chen,Aimin Wu

Journal of clinical biochemistry and nutrition 75:190-196 PubMed39583972

2024

Effect of cerium oxide on iron metabolism in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yuki Kanome,Shunki Ohtomo,Masaharu Nakatsu,Masahiro Kohno,Koji Fukui

CNS neuroscience & therapeutics 30:e70054 PubMed39306799

2024

KA-mediated excitotoxicity induces neuronal ferroptosis through activation of ferritinophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Yue Jiang,Wei-Long Wu,Jia-Ni Huang,Na Liu,Jing Wang,Xiao-Rui Wan,Zheng-Hong Qin,Yan Wang

Frontiers in endocrinology 13:1048818 PubMed36818465

2023

PTH 1-34 promoted bone formation by regulating iron metabolism in unloading-induced bone loss.

Applications

Unspecified application

Species

Unspecified reactive species

Jingmin Che,Weihao Ren,Xin Chen,Fang Wang,Gejing Zhang,Peng Shang

Frontiers in immunology 13:985538 PubMed36713405

2023

Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis.

Applications

Unspecified application

Species

Unspecified reactive species

Sandeep R Kaushik,Sukanya Sahu,Hritusree Guha,Sourav Saha,Ranjit Das,Rukuwe-U Kupa,Wetetsho Kapfo,Trinayan Deka,Rumi Basumatary,Asunu Thong,Arunabha Dasgupta,Bidhan Goswami,Amit Kumar Pandey,Lahari Saikia,Vinotsole Khamo,Anjan Das,Ranjan Kumar Nanda

Autophagy 19:1997-2014 PubMed36647288

2023

PRMT1 driven PTX3 regulates ferritinophagy in glioma.

Applications

Unspecified application

Species

Unspecified reactive species

Kirti Lathoria,Pruthvi Gowda,Sonia B Umdor,Shruti Patrick,Vaishali Suri,Ellora Sen

Journal of orthopaedic translation 38:126-140 PubMed36381248

2022

1-2 T static magnetic field combined with Ferumoxytol prevent unloading-induced bone loss by regulating iron metabolism in osteoclastogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Gejing Zhang,Chenxiao Zhen,Jiancheng Yang,Zheyuan Zhang,Youde Wu,Jingmin Che,Peng Shang

Redox biology 57:102509 PubMed36302319

2022

Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model.

Applications

Unspecified application

Species

Unspecified reactive species

Zhuo Pei,Yifei Qin,Xianghui Fu,Fengfan Yang,Fei Huo,Xue Liang,Shijie Wang,Hongyong Cui,Peng Lin,Gang Zhou,Jiangna Yan,Jiao Wu,Zhi-Nan Chen,Ping Zhu

Redox report : communications in free radical research 27:119-127 PubMed35735222

2022

Norcantharidin down-regulates iron contents in the liver and spleen of lipopolysaccharide-treated mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Zheng,Jiao-Jiao Wang,Hui-Min Ma,Meng-Qi Shen,Zhong-Ming Qian,Yu-Xin Bao

Nature communications 13:676 PubMed35115492

2022

TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models.

Applications

Unspecified application

Species

Unspecified reactive species

Jiao Wu,Zhuan Feng,Liang Chen,Yong Li,Huijie Bian,Jiejie Geng,Zhao-Hui Zheng,Xianghui Fu,Zhuo Pei,Yifei Qin,Liu Yang,Yilin Zhao,Ke Wang,Ruo Chen,Qian He,Gang Nan,Xuejun Jiang,Zhi-Nan Chen,Ping Zhu

View all publications

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Anti-SLC40A1 抗体

Anti-SLC40A1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC40A1 antibody (AB78066)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC40A1 antibody (AB78066)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC40A1 antibody (AB78066)