AB262851

Anti-SIGLEC6抗体

Name: SIGLEC6抗体 (ab262851)| Abcam中文官网
Brand: Abcam Limited
SKU: AB262851
Price: 5791 CNY
Availability: InStock

Anti-SIGLEC6 antibody

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(2 Publications)

Rabbit Polyclonal SIGLEC6 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SIGLEC6 aa 350 to C-terminus.

查看别名

CD327, CD33L, CD33L1, OBBP1, SIGLEC6, Sialic acid-binding Ig-like lectin 6, Siglec-6, CD33 antigen-like 1, CDw327, Obesity-binding protein 1, OB-BP1

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC6 antibody (AB262851)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC6 antibody (AB262851)

Paraffin-embedded Human liver tissue stained for SIGLEC6 using ab262851 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC6 antibody (AB262851)

Paraffin-embedded Human prostate tissue stained for SIGLEC6 using ab262851 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC6 antibody (AB262851)

Paraffin-embedded Human testis tissue stained for SIGLEC6 using ab262851 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC6 antibody (AB262851)

Paraffin-embedded Human placenta tissue stained for SIGLEC6 using ab262851 at 1/500 dilution in immunohistochemical analysis.

Unknown

Western blot - Anti-SIGLEC6 antibody (AB262851)

All lanes:

Western blot - Anti-SIGLEC6 antibody (ab262851) at 0.4 µg/mL

All lanes:

SIGLEC6-overexpressed HEK-293T lysate

Predicted band size: 49 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human SIGLEC6 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O43699

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.4 µg/mL", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SIGLEC6 also known as CD327 is a protein found on some immune cells particularly on B cells and to a lesser extent on macrophages and dendritic cells. This protein has a molecular mass of around 100 kDa. As a member of the sialic acid-binding immunoglobulin-type lectins family (siglecs) SIGLEC6 mechanistically functions by recognizing and binding to specific sialic acid-containing carbohydrates on cell surfaces. This recognition influences cell-cell interactions and signaling processes important for immune response modulation.

Biological function summary

SIGLEC6 serves as an inhibitory receptor that helps dampen B cell receptor signaling balancing the immune response to prevent overactivation. It often partners with other proteins in complex cellular interactions within the immune cells. The expression of SIGLEC6 in placental tissues also suggests a role in trophoblast invasion and development although this function requires more research to fully understand the mechanisms involved.

Pathways

SIGLEC6 is a part of the B cell receptor signaling pathway acting as an inhibitory modulator. Through this pathway it connects with proteins like CD22 and other siglecs that contribute to the regulation of B cell activity. Additionally its role in glycan recognition links it to pathways associated with cell surface interactions and immune tolerance.

SIGLEC6 expression alterations have implications in chronic lymphocytic leukemia (CLL) where it potentially influences disease progression by modulating B cell signaling. The protein has also been connected to gestational trophoblastic diseases potentially affecting placental development. In these contexts SIGLEC6 interacts with proteins such as CD22 in CLL where they collectively affect leukemic cell behaviors and disease outcomes.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

See full target information SIGLEC6

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 13:1528714 PubMed39996028

2025

The regulatory role of placental extracellular vesicle on trophoblast and endothelial cell functions.

Applications

Unspecified application

Species

Unspecified reactive species

Kunfeng Bai,Xintong Li,Yanjie Guo,Ye Shang,Leqian Lin,Philip C N Chiu,Cheuk-Lun Lee

eLife 11: PubMed35975985

2022

Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface.

Applications

Unspecified application

Species

Unspecified reactive species

Liheng Yang,Eleanor C Semmes,Cristian Ovies,Christina Megli,Sallie Permar,Jennifer B Gilner,Carolyn B Coyne

View all publications

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Anti-SIGLEC6抗体

Anti-SIGLEC6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC6 antibody (AB262851)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC6 antibody (AB262851)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC6 antibody (AB262851)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC6 antibody (AB262851)

Western blot - Anti-SIGLEC6 antibody (AB262851)