Anti-SIGLEC11抗体(ab106390)
Key features and details
- Rabbit polyclonal to SIGLEC11
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SIGLEC11抗体
参阅全部 SIGLEC11 一抗 -
描述
兔多克隆抗体to SIGLEC11 -
宿主
Rabbit -
特异性
Specific to Human SIGLEC11, does not cross react with SIGLEC10. -
经测试应用
适用于: ICC/IF, WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
18 amino acid peptide from near the carboxy terminus of Human SIGLEC11 (NP_443116).
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阳性对照
- HepG2 cell lysate Human liver tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at 4°C (stable for up to 12 months). -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab106390于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF |
Use a concentration of 20 µg/ml.
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| WB |
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 76 kDa.
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| IHC-P |
Use a concentration of 5 µg/ml.
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| 说明 |
|---|
|
ICC/IF
Use a concentration of 20 µg/ml. |
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WB
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 76 kDa. |
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IHC-P
Use a concentration of 5 µg/ml. |
靶标
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功能
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. -
组织特异性
Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia. -
序列相似性
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
结构域
Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. -
翻译后修饰
Phosphorylated on tyrosine residues. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 114132 Human
- Omim: 607157 Human
- SwissProt: Q96RL6 Human
- Unigene: 661852 Human
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别名
- sialic acid binding Ig like lectin 11 antibody
- sialic acid binding lectin 11 antibody
- Sialic acid-binding Ig-like lectin 11 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC11 antibody (ab106390)ab106390 at 5µg/ml, staining SIGLEC11 in Human liver, using Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.
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Immunocytochemistry/ Immunofluorescence - Anti-SIGLEC11 antibody (ab106390)Immunofluorescence of SIGLEC11 in Human liver tissue with ab106390 at 20 ug/mL.
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Western blot - Anti-SIGLEC11 antibody (ab106390)Anti-SIGLEC11 antibody (ab106390) at 1 µg/ml + HepG2 cell lysate at 15 µg
Predicted band size: 76 kDa
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab106390 被引用在 1 文献中.
- Narta K et al. Whole Exome Sequencing Reveals Novel Candidate Genes in Familial Forms of Glaucomatous Neurodegeneration. Genes (Basel) 14:N/A (2023). PubMed: 36833422