重组Anti-SIGIRR抗体[EPR12638] (ab177937)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR12638] to SIGIRR
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
Related conjugates and formulations
概述
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产品名称
Anti-SIGIRR抗体[EPR12638]
参阅全部 SIGIRR 一抗 -
描述
兔单克隆抗体[EPR12638] to SIGIRR -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: ICC/IF,IHC-P or IP -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Synthetic peptide within Human SIGIRR aa 1-100 (Cysteine residue). The exact sequence is proprietary.
Database link: Q6IA17 -
阳性对照
- Fetal kidney lysate.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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纯度
Tissue culture supernatant -
克隆
单克隆 -
克隆编号
EPR12638 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab177937于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 46 kDa.
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说明 |
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WB
1/1000 - 1/10000. Predicted molecular weight: 46 kDa. |
靶标
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功能
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. -
组织特异性
Mainly expressed in epithelial tissues such as kidney, lung and gut. -
序列相似性
Belongs to the interleukin-1 receptor family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 TIR domain. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 59307 Human
- Entrez Gene: 24058 Mouse
- Entrez Gene: 309106 Rat
- Omim: 605478 Human
- SwissProt: Q6IA17 Human
- SwissProt: Q9JLZ8 Mouse
- SwissProt: Q4V892 Rat
- Unigene: 501624 Human
see all -
别名
- Ig IL1 related receptor antibody
- MGC110992 antibody
- SIGIR_HUMAN antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab177937 被引用在 2 文献中.
- Bodaszewska-Lubas M et al. Dominant-Negative Form of SIGIRR: SIGIRRΔE8 Promotes Tumor Growth Through Regulation of Metabolic Pathways. J Interferon Cytokine Res 42:482-492 (2022). PubMed: 35900274
- Gao T et al. Platelet-activating factor induces the stemness of ovarian cancer cells via the PAF/PAFR signaling pathway. Am J Transl Res 12:7249-7261 (2020). PubMed: 33312364